hirudin is an anticoagulant agent of the salivary glands of the medicinal leech. recombinant hirudin (r-hir) displays certain drawbacks including bleeding and immunogenicity. to solve these problems, cysteine-specific pegylation has been proposed as a successful technique. however, proper selection of the appropriate cysteine residue for substitution is a critical step. this study has, for the ...

micropapillary variant of urothelial carcinoma (uc) of the bladder is an aggressive tumour, comprising 0.6-6% of all uc. it generally presents with high-grade and stage, and has been reported as having a worse prognosis when compared to traditional uc. we report the case of a 58-year-old man who presented with macroscopic haematuria. the patient was diagnosed with high-grade urothelial carcinom...

staphylococcus aureus produces a particular morphological variant called small colony variant (scv) which is responsible for persistent subclinical infections in predisposed individuals and is usually resistant to aminoglycosides and cell wall active antibiotics. infections by scv of s. aureus are an upcoming problem due to difficulty in laboratory diagnosis and resistance to antimicrobial chem...

acute myocardial infarction (mi) during pregnancy is rare and mi due to prinzmetal's angina is much rarer. we present a 35-year-old, obese, multigravida, and pre-eclamptic woman, who developed acute anterior wall mi at the 30th week of gestation. on coronary angiography, the second obtuse marginal branch was totally occluded and the right coronary artery (rca) was normal. three days later, she ...

vibrio cholerae o1 are classified into two biotypes, classical and el tor based on susceptibility to bacteriophages and some biochemical properties, each encoding a biotype-specific genetic determinants. before 1961, most epidemics had been caused by the classical biotype. however, with the passage of time, the classical biotype missed from the scenario and the el tor emerged as the major bioty...

background: the study of specific genes expressed in the testis is important to understanding testis development and function. spermatogenesis is an attractive model for the study of gene expression during germ cell differentiation. spermatogenesis associated-19 (spata-19) is a recently-identified important spermatogenesis-related gene specifically expressed in testis. its protein product is in...

The witches’ broom disease of lime trees is a destructing disease caused by the bacterium Candidatus <span style="font-variant: normal; fon...

purpose: to evaluate the prevalence, natural course, and final visual acuity in patients with stages iii or iv of diffuse lamellar keratitis (dlk) following laser in situ keratomileusis  (lasik). methods: in this descriptive study, records of all the patients who underwent lasik surgery in two private excimer laser clinics were reviewed. according to linebarger- lindstrom-hardten classification...

non-hodgkin lymphoma usually presents with generalized lymphadenopathy, but it can also involve any part of the human body. lymphomatous involvement of muscles is a rare presentation and has been reported to occur in only 1.1% in non-hodgkin lymphoma. here we, present a 32 year-old iranian man with primary involvement of spleen, bone, bone marrow and muscle, mimicking soft tissue sarcoma; core ...

in this research, cobalt and nickel sulfide nanoparticles (nps) were grown on almcm-41 matrix by using ion exchange method. the prepared samples were irradiated by thermalized neutron that emitted from am-be source up to fluencies (7.9+e9n/cm2). after that, x-ray diffraction (xrd), uv-vis spectroscopy, fourier transform infrared (ftir), scanning electron microscopy (sem) and transmission electr...