RATIONALE AND OBJECTIVES The aims of this study were to determine the feasibility of diffusion-weighted magnetic resonance imaging (DWI) in the detection of bowel inflammation and to investigate the changes in apparent diffusion coefficient (ADC) values in the inflamed bowel in patients with Crohn's disease. MATERIALS AND METHODS Eleven patients who underwent magnetic resonance enterography (...

Introduction: Diffusion-weighted imaging (DWI) is a powerful tool for the evaluation of radiation therapy since the apparent diffusion coefficient (ADC) provides information about tumor viability [1]. Problems may arise, however, when DWI is used in the presence of paramagnetic particles, e.g., to evaluate the effect of internal radiation therapy of liver tumors using Holmium-166 loaded microsp...

Image distortion caused by gradient eddy currents is a major problem in the use of diffusion tensor imaging (DTI), as using the uncorrected images for calculation of apparent diffusion coefficient (ADC) and diffusion anisotropy will result in areas of artificially increased anisotropy and ADC at the edge of the images, as well as decreased spatial resolution and accuracy in ADC computations ove...

Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion and diffusion magnetic resonance imaging every 30 minutes for 3 hours. The normal left-hemisphere apparent diffusion coefficient (ADC) was 0.76 +/- 0.03 x 10(-3) mm(2)/s and CBF was 0.7 +/- 0.3 mL x g(-1) x min(-1) (mean +/- SD, n=5). The ADC and CBF viability ...

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative high-resolution (200 x 200 microm) cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) were measured on acute stroke rats subjected to permanent middle cerebral artery occlusion and an automated clustering (ISODATA) technique was used to classify ischemic tissue types....

This study aimed to investigate the potential of intravoxel incoherent motion (IVIM) diffusion-weighted MR imaging in assessing solitary pulmonary lesions (SPLs). Sixty-two patients with pathologically confirmed SPLs, including 51 and 11 cases of malignant and benign lesions, respectively, were assessed. Diffusion weighted imaging (DWI) with 13 b values was used to derive apparent diffusion coe...

The purpose of this work was to reliably acquire and evaluate diffusion tensor data of the cervical spine. Thereto, we describe an optimized, time-efficient inner-volume echo planar imaging sequence. Multislice capability is achieved by restoring the magnetization in neighbouring slices early during the twice refocused diffusion preparation. The acquired diffusion images showed compelling image...

Diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) were performed on a healthy 31-year-old man with asymptomatic lumbar disc herniation. Although the left S1 nerve root was obviously entrapped by a herniated mass, neither DWI nor DTI showed any significant findings for the nerve root. Decreased apparent diffusion coefficient (ADC) values and increased fractional anisotropy (FA)...

BACKGROUND There is evidence for neurosyphilis being associated with the central nervous system vasculitis involving medium and small vessels. As the hemispheric white matter is the major target of these vascular alterations the white matter axonal and myelination disruption may be observed employing measure for the rate of water molecule diffusion. High apparent diffusion coefficient (ADC) cor...

OBJECTIVE To establish a cerebral hypoxia ischaemic model in piglets and to explore the early diffusion weighted imaging (DWI) as well as the expression of heat shock protein 70 (HSP70) with hypoxic ischaemic encephalopathy (HIE). METHODS Twenty four 3 day old piglets were permanently ligated common carotid arteries bilaterally and ventilated with 3% oxygen for 30 minutes, and their brains we...