Introduction: Percutaneous transluminal coronary angioplasty (PTCA) is an effective method for revascularizing of stenotic coronary vessels. Lack of response to this treatment, either in symptomatic or asymptomatic patients, is usually due to incomplete revascularization, restenosis, and/or irreversibility of myocardial perfusion. Introduction of a noninvasive method with high predictive value ...

OBJECTIVES This study evaluated the diagnostic value of dipyridamole plus low level treadmill exercise (dipyridamole stress) thallium-201 single-photon emission computed tomography (SPECT) in patients taking antianginal drugs. BACKGROUND Dipyridamole stress is the major substitute for maximal exercise in patients referred for myocardial perfusion imaging. Although antianginal drugs are common...

OBJECTIVES The goal of this study was to compare regadenoson and dipyridamole hyperemia for quantitative myocardial perfusion imaging. BACKGROUND Regadenoson is commonly used for stress perfusion imaging. However, no study in nuclear cardiology has employed a paired design to compare quantitative hyperemic flow from regadenoson to more traditional agents such as dipyridamole. Additionally, th...

Radionuclide myocardial perfusion imaging (MPI) plays a vital role in the evaluation and management of patients with coronary artery disease. However, because of a steep growth in MPI in the mid 2000s, concerns about inappropriate use of MPI and imaging-related radiation exposure increased. In response, the professional societies developed appropriate-use criteria for MPI. Simultaneously, novel...

OBJECTIVES The present study was designed to compare the absolute myocardial blood flow (MBF) after intravenous dipyridamole infusion with that during dobutamine-atropine administration in normal healthy male volunteers. BACKGROUND Both safety and usefulness of dobutamine-atropine stress in myocardial perfusion imaging have been reported. However, no information exists on whether the magnitud...

Objective: The ankle-brachial index (ABI) as a simple test which can detect peripheral arterial disease (PAD). Therefore in this study we try to evaluate the diagnostic value of ABI for silent myocardial ischemia in diabetic patients and compare the results with myocardial perfusion imaging (MPI) results. Materials and Methods: All 149 diabetic patients in this study were categorized according...

Myocardial perfusion imaging (MPI) is a wellestablished noninvasive method of assessing coronary blood flow.1–5 MPI is capable of identifying regional abnormalities in coronary artery blood flow and determining their physiological relevance to myocardial function and viability. MPI requires the intravenous injection of a radioactive blood flow marker followed by imaging of regional myocardial u...

or more than 2 decades, myocardial perfusion imaging (MPI) has been one of the best clinical tools for guiding clinicians in the management of patients with suspected or known coronary artery disease (CAD). MPI has been considered the best noninvasive imaging modality for measuring myocardial blood flow. The presence of significant ischemia on MPI usually necessitates further evaluation with co...

BACKGROUND Glucose intolerance is a major health problem and is associated with increased risk of progression to type 2 diabetes mellitus and cardiovascular disease. However, whether glucose intolerance is related to impaired myocardial perfusion is not known. The purpose of the present study was to study the effect of diet-induced glucose intolerance on myocardial function and perfusion during...

Dear Sir, the recent issue of Nuclear Medicine Review published an interesting study by Gholamrezanezhad et al. regarding rate dependent left bundle branch block and its effect on myocardial perfusion SPECT [1]. They reported four cases with rate dependent LBBB during exercise stress for myocardial perfusion imaging. Myocardial perfusion SPECT imaging showed no evidence of reversible perfusion ...