نتایج جستجو برای: direct mutagenesis

تعداد نتایج: 451037  

Journal: :Malaysian Journal of Fundamental and Applied Sciences 2021

The effects of gamma radiation are investigated by studying seed germination, survival rate and morphological characteristics Stevia rebaudiana. Improvement stevia plant through mutagenesis could be one the ways to produce with delay flowering.

2013
Manal Hassan Eed

The Resistance to SaH of Brassica sps. and Improved Resistance by Direct Selection and Mutagensis

Journal: :Genetics 2008
Gary E Schultz John W Drake

Some mutations arise in association with a potential sequence donor that consists of an imperfect direct or reverse repeat. Many such mutations are complex; that is, they consist of multiple close sequence changes. Current models posit that the primer terminus of a replicating DNA molecule dissociates, reanneals with an ectopic template, extends briefly, and then returns to the cognate template...

Journal: :Current opinion in microbiology 1998
J S Brown D W Holden

Screening insertional mutants for loss of virulence is an effective method for investigating the molecular genetic basis of bacterial pathogenesis, but has only recently been applied to fungal pathogens. For many pathogenic fungi transformation with heterologous plasmid DNA results in complex integration events. This problem can now be circumvented for some species using restriction enzyme medi...

Journal: :Human Molecular Genetics 1999

Journal: :Acta Materia Medica 2022

Signal transducer and activator of transcription 3 (STAT3) plays a key role in promoting tumor malignant progression. Suppression hyperactivated STAT3 signaling has emerged as potential therapeutic strategy for many cancer types. In this study, the effect 6-ethoxydihydrosanguinarine (6-EDS), secondary transformation product formed from dihydrosanguinarine, isolated Macleaya (Papaveraceae), was ...

Journal: :Genetics 2013
Robert S Dwyer Dante P Ricci Lucy J Colwell Thomas J Silhavy Ned S Wingreen

The essential outer membrane β-barrel protein BamA forms a complex with four lipoprotein partners BamBCDE that assembles β-barrel proteins into the outer membrane of Escherichia coli. Detailed genetic studies have shown that BamA cycles through multiple conformations during substrate assembly, suggesting that a complex network of residues may be involved in coordinating conformational changes a...

2012
Luca Biasco Cristina Baricordi Alessandro Aiuti

γ-Retroviral and lentiviral vectors allow the permanent integration of a therapeutic transgene in target cells and have provided in the last decade a delivery platform for several successful gene therapy (GT) clinical approaches. However, the occurrence of adverse events due to insertional mutagenesis in GT treated patients poses a strong challenge to the scientific community to identify the me...

Journal: :Environmental Health Perspectives 1977

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