We aligned Incyte ESTs and publicly available sequences to the rat genome and analyzed rat chromosome 1q43-54, a region in which several quantitative trait loci (QTLs) have been identified, including renal disease, diabetes, hypertension, body weight, and encephalomyelitis. Within this region, which contains 255 Ensembl gene predictions, the aligned sequences clustered into 568 Incyte genes and...

Although several molecular and genetic manipulations may produce hyperactive animals, hyperactivity alone is insufficient for the animal to qualify as a model of ADHD. Based on a wider range of criteria - behavioral, genetic and neurobiological - the spontaneously hypertensive rat (SHR) obtained from Charles River, Germany (SHR/NCrl) at present constitutes the best validated animal model of ADH...

The objective of this study was to determine the effect Apis dorsata forest honey on liver histopathological changes white rats (Rattus norvegicus) exposed physical stress. This used 24 which were divided into 4 groups. positive control group (C+) only given a stressor and distilled water orally, treatment 1 (T1) + 2g/rat/day, T2 4g/rat/day, T3 6g/rat/day. All treatments carried out within 14 d...

As a disease model, the laboratory rat has contributed enormously to neuroscience research over the years. It has also been a popular animal model for Alzheimer's disease but its popularity has diminished during the last decade, as techniques for genetic manipulation in rats have lagged behind that of mice. In recent years, the rat has been making a comeback as an Alzheimer's disease model and ...

Haemophilus influenzae is an important cause of invasive disease. The infant rat is the accepted model of invasive H. influenzae disease. Here, we report the genome sequences of six nontypeable H. influenzae strains that establish bacteremia in the infant rat.

sporadic alzheimer’s disease (sad) is affected by genetic risk factors, aging and oxidative stresses. the herbal extract of r. canina, t. vulgare and u. dioica has a beneficial role in aging, as an anti-inflammatory and anti-oxidative agent. we investigate the neuroprotective effects of this herbal extract in the rat model of sad.  the rats were divided into control, sham, model, herbal extract...

Abstract The purpose of this work was to develop and evaluate a deep learning approach for automatic rat brain image segmentation magnetic resonance imaging (MRI) images in clinical PET/MR, providing useful tool analyzing studies the pathology progression neurological disease validate new radiotracers therapeutic agents. Rat PET/MR ( N = 56) were collected from system using dedicated small-anim...

Background The development and characterization of biomarkers abnormalities in Alzheimer’s disease (AD) animal models is particularly important for the investigation pathophysiological mechanisms drug development. With this mind, here, we aimed at characterizing brain glucose metabolism, indexed by [18F]FDG-microPET, TgF344-AD rat, a model harboring human APP/PS1 mutations. We hypothesized earl...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Li R, Jin S, He J, Peng Y, Wei L, Gu L. Exercise attenuates neuronal degeneration in Parkinson’s disease rat model by regulating the level of adenosine 2A receptor. Folia Neuropathologica. 2023. doi:10.5114/fn.2023.125120. APA Li, R., Jin, S., He, J., Peng, Y., Wei, L., & Gu, (2023). https://doi.org/10.5114/fn.202...

Foreign body ingestions are common medical emergencies. In adults, foreign occur in patients with psychiatric disorders and prison inmates. A majority (80-90%) of bodies pass spontaneously. Endoscopic surgical interventions required only 10-20% 1%, respectively. plain radiograph may be the diagnostic test required. computed tomography scan needed when a perforation is suspected. Food boluses mo...