The experimental vibrational circular dichroism, electronic circular dichroism, and optical rotatory dispersion spectra and corresponding quantum chemical predictions of 3,3'-diphenyl-[2,2'-binaphthalene]-1,1'-diol (VANOL) are used to confirm its absolute configuration as (+)(589)-(aR) or (-)(589)-(aS). A discrepancy in the literature crystal structure has been resolved by determining the X-ray...

When the SH groups of various derivatives of human haemoglobin are converted into their mercuric mercaptides small changes are observed in the optical rotatory dispersion in the range 385-294mmu. These changes are proportionately greater for the reactive than for the unreactive SH groups. These observations have been interpreted in terms of the conformational changes that are likely to occur in...

One of the factors which limits the transmission capacity of the fiber optics communication channel is the material dispersion. Exact analytical study of the material dispersion is often complex and involves calculating the derivatives of the refractive index of the core. These calculations are too cumbersome to do, especially for high-order derivatives. So material dispersion has only been stu...

Objective(s):Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib (CLX). Materials and Methods: Solid dispersions of CLX:PVP or CLX:PLX were prepared at different r...

The axial dispersion coefficient of hexachlorobenzene in supercritical carbon dioxide is investigated in a fixed-bed packed with glass beads. The on-line chromatographic pulse-response experiment is used in order to study the dynamics of a packed column under supercritical conditions. The radial dispersion is assumed negligible because of the packed column geometry. To estimate the axial disper...

background: myocardial ischemia is one of several causes of prolonged qt dispersion. the aim of this study was to evaluate the effect that percutaneous coronary intervention has on the depolarization and repolarization parameters of surface electrocardiography in patients with chronic stable angina. methods: we assessed the effects of full revascularization in patients with chronic stable angin...

the effect of mixing on rheological behavior of 6% wt epoxy-clay nanocomposites was studied. the mixing processes were carried out by low shear mixer, homogenizer and ultrasonic and combination of different mixing techniques at medium and maximum power. all these methods led to intercalated structure. the xrd results showed that the ultrasonic has the best effect on dispersion while a low shear...

the first aim of the present investigation was to prepare solid dispersions to improve the dissolution properties of oxcarbazepine and quetiapine using peg 6000 as a carrier with the help of two methods of preparations viz. spray drying and modified solvent method, and to compare the two methods. the second objective was to apply the modified solvent method for preparation of sustained release ...