poorly water-soluble drugs often suffer from limited or irreproducible clinical response due to their low solubility and dissolution rate. in this study, organic solvent-free solid dispersions (osf-sds) containing telmisartan (tel) were prepared using polyvinylpyrrolidone k30 (pvp k30) and polyethylene glycol 6000 (peg 6000) as hydrophilic polymers, sodium hydroxide (naoh) as an alkalizer, and ...

Background: Cardiovascular mortality and morbidity are high in chronic renal failure (CRF) patients. Increased dispersion of QT intervals is known to predispose to ventricular arrhythmias and sudden cardiac death. This study was conducted to assess the effect of hemodialysis (HD) on corrected QT (QTc) intervals and their dispersions (QTd) in chronic hemodialyzed patients. Methods: Fifty-eight p...

Aqueous dispersions of fullerene C60 were prepared from fulleride solutions in tetrahydrofuran, followed by air oxidation, transfer to water and solvent evaporation. Fulleride exposition produces charged THF that can be transferred produce aqueous dispersions, stable for months.

background: cardiovascular mortality and morbidity are high in chronic renal failure (crf) patients. increased dispersion of qt intervals is known to predispose to ventricular arrhythmias and sudden cardiac death. this study was conducted to assess the effect of hemodialysis (hd) on corrected qt (qtc) intervals and their dispersions (qtd) in chronic hemodialyzed patients. methods: fifty-eight p...

Graphite is exfoliated in water to give dispersions of mono- and few-layer graphene stabilized by surfactant. These dispersions can be used to form thin, disordered films of randomly stacked, oxide-free, few-layer graphenes. These films are transparent with a direct current conductivity of up to 1.5 x 10(4) S m(-1). The conductivity is stable under flexing for at least 2000 cycles. The electric...

aim: to enhance the aqueous solubility of olanzapine by using the solid dispersion technique. solid dispersions of olanzapine were prepared by the dispersion method using using pgs and ssg as carriers. drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...

Physics, Moscow, RussiaWe consider cholesteric liquid-crystalline DNA dispersions, and show thatpolymeric (Dau-Cu) complexes, the so-called bridges, between pairs of DNA molecules may generate a super liquid-crystalline structure (BR-phase), charachterized by a soliton lattice of the spatial distribution of theorder parameter. The BR-phase could have a layered spatial structure andan abnormal o...

We estimate investment style dispersions for individual actively managed equity mutual funds, which describe how widely fund investments are distributed around the core fund style along the dimensions of size, book-to-market, and momentum, respectively. We find that high style dispersions, especially that along the size dimension, are associated with superior fund performance, consistent with h...

We examine the X–ray luminosity of galaxy groups in the CNOC2 survey, at redshifts 0.1 < z < 0.6. Previous work examining the gravitational lensing signal of the CNOC2 groups has shown that they are likely to be genuine, gravitationally bound objects. Of the 21 groups in the field of view of the EPIC–PN camera on XMM–Newton, not one was visible in over 100 ksec of observation, even though three...

Solid dispersions of tanshinone IIA (TanIIA) using hydroxyapatite (HAp) as the dispersing carrier (TanIIA-HAp SDs) were prepared by the solvent evaporation method. The formed solid dispersions were characterized by scanning electron microscopy (SEM), differential scanning calorimetry analysis (DSC), X-ray powder diffraction (XRPD) and Fourier transforms infrared (FTIR) spectroscopy. The in vitr...