clarithromycin (clm) is a member of macrolide family with broad spectrum antibiotic activity. it is practically insoluble in water and its poor solubility is ph dependent. in this study, series of nanosuspensions containing clm and stabilizer such as hpmc, nacmc, polysorbate 80, poloxamer 188 and polyvinyl alcohol in various ratios were prepared using sonoprecipitation method. briefly, clm was ...

Irbesartan, a widely prescribed anti hypertensive drug belongs to class II under BCS classification and exhibit low and variable oral bioavailability due to its poor aqueous solubility. It needs enhancement in the dissolution rate in its formulation development. Complexation with β-cyclodextrin (βCD) and use of Crospovidone and PVP K 30 are tried for enhancing the dissolution rate of irbesartan...

In this second of two articles, we show that several supercritical processes have been developed to prepare composite particles of poorly soluble active ingredients. Microencapsulation, cyclodextrin inclusion and impregnation allow to incorporate poorly soluble materials in fast-dissolving hydrophilic excipients, leading to promising results in terms of dissolution rate enhancement.

The aim was to enhance the dissolution of lornoxicam (LOR) and to produce mini-tablets with an optimised system to provide a rapid-release multi-particulate formulation. LOR systems were prepared through co-evaporation with either polyethylene glycol 6000 or Pluronic(®) F-68 (PLU) and adsorption onto Neusilin(®) US2 alone or co-adsorption in the presence of different amounts of polysorbate 80. ...

Objective: Solubility is a key parameter as it is one of the main causes for poor bioavailability. The objective was to improve the solubility and dissolution profile of poorly-soluble silymarin with a water-soluble carrier fulvic acid. Materials and methods: Phase solubility studies were carried out for the determination of stoichiometric ratio between silymarin and fulvic acid by Higuchi and ...