Nematocytes in Hydra differentiate from interstitial stem cells. Desmonemes differentiate mainly in the distal half of the body column while stenoteles differentiate predominantly in the proximal half. This difference was used to determine the timing of nematocyte-type commitment in the differentiation pathway. Cells were transferred from distal or proximal regions to all positions in the body ...

Point mutations in WNK4 [for With No K (lysine)], a serine-threonine kinase that is expressed in the distal nephron of the kidney, are linked to familial hyperkalemic hypertension (FHH). The imbalanced electrolyte homeostasis in FHH has led to studies toward an understanding of WNK4-mediated regulation of ion transport proteins in the kidney. A growing number of ion transport proteins for Na(+)...

objective: prostate cancer is the fifth most common cancer. in 2012, it was the second leading cause of cancer death for men worldwide. the pi3k/akt pathway plays an essential role in pathogenesis of prostate cancer; the key role of this pathway in cancer progression makes it an attractive target for prostate cancer therapy. micrornas (mirnas) that regulate gene expression have a special abilit...

Background Neoplastic adenomatous polyps generating from the epithelial cells are considered benign tumors. Adenomatous polyps are common in western countries and it can take seven to 10 or more years for an adenoma to evolve into cancer.  The Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway, is a signaling pathway that controls organ size in animals through the r...

aim : the aim of this study was to report the anatomical location and histologic type of colorectal polyps in a large series of iranian patients that attended for colonoscopy. background : polyps that develop through the adenoma-carcinoma pathway are considered neoplastic and may eventually progress to invasive carcinomas. in addition polyps can develop with no neoplastic potential. these neopl...

The last 2 decades have been marked by concerted search for the gene or genes which would account for schizophrenia. It has become increasingly obvious to many investigators in the field that these genes are not going to be found. Schizophrenia is not likely a simple genetic disorder nor is it likely accounted for by a few major genes. Where does this leave us? Some have suggested that a more p...

INTRODUCTION In children and adolescents distal forearm physeal fractures are common. Usually distal forearm physeal injuries of are common injuries in children and adolescents. Epiphyseal injuries to the distal radius are common in children, but involvement of the distal ulna is rare. Fracture of the distal radius with dislocation of the DRUJ is known as a True Galeazzi fracture dislocation an...

conclusions hematoma block analgesia used in distal radius fractures of the elderly is a very safe and effective method that seems preferable to general anesthesia in emergency departments. objectives the aim of this study was to compare two analgesia methods including hematoma block and general anesthesia in people over 60 years in the orthopedic emergency department. methods 68 elderly patien...

background:  fractures of the distal third of the tibia are mostly associated with a fibular fracture that often requires fixation. the preferred treatment of distal tibial fracture is the minimally invasive percutaneous plate osteosynthesis  (mippo) procedure. however, there are no clear cut guidelines on fixation of the fibular fracture and currently most orthopedic surgeons use a plate osteo...