Nasopharyngeal carcinoma (NPC) has a high metastatic character in the clinic, but its mechanism is not clear. As a carcinogen with organ specificity for the nasopharyngeal epithelium, N,N'-Dinitrosopiperazine (DNP) is involved in NPC metastasis. Herein, our data revealed that anterior gradient 2 (AGR2) was overexpressed in human NPC tissues, particularly in cervical lymph node metastatic NPC (L...

Early and late antisera to 2, 4-dinitrophenyl (DNP) and to menadione (K3)4 were compared for reactivity with diverse DNP and K3 ligands. Late antisera were generally more reactive (higher affinity) than early antibodies. Nevertheless, the early antibodies had higher affinity for homologous ligands than late antibodies had for heterologous ligands; the exception, a small (ca. 5%) and possibly he...

1 To determine the role of actin assembly in the Ca signalling of mast cells activated by crosslinking of FceRI, we examined the e€ects of cytochalasin D, an inhibitor of actin polymerization. 2 In the RBL-2H3 cells, F-actin content was increased by sensitization with anti-dinitrophenol (DNP) IgE. In these cells, cytochalasin D induced oscillatory increases in cytosolic Ca ([Ca]i); these increa...

桑原幹典,林 正信,吉 井義一:北 海道大学獣 医学 部放射 線学 教室,札 幌市北区北18条 西9丁 目,〒060 When the solid-state deoxyribonucleoprotein (DNP) was irradiated by gamma rays, Lucke Huhle et al.1) found that single strand breaks of DNA were produced more frequently in the DNP than in pure DNA. Ormerod2) and Kuwabara and Yoshii3) reported that the ESR spectra of DNP after irradiation showed radicals to be located preferentially on ...

Genetic nonresponder guinea pigs incapable of an immune response to DNP-PLL alone were immunized with DNP-PLL complexed to ovalbumin or bovine serum albumin. Under these circumstances the animals produce both anti-DNP-PLL antibodies and antibodies directed against the conveyor albumin. Thus immune response to DNP-PLL complexed to conveyor albumin molecules can serve as a simple model of hapten-...

Both electrically induced exercise and infusion of 2,4-dinitrophenol (DNP) increased oxygen consumption and tissue metabolism in chloralose-anesthetized dogs. Cardiac output increased with oxygen consumption at the same rate in both experimental conditions. The increase in cardiac output induced by exercise was, as expected, accompanied by increases in both lactate-to-pyruvate ratio and "excess...

Recently, dynamic nuclear polarization enhanced nuclear magnetic resonance (DNP/NMR) has emerged as a powerful technique to obtain significant enhancements in spin spectra from biological samples. For DNP in modern NMR systems, a high power continuous-wave source in the submillimeter wavelength range is necessary. Gyrotrons can deliver tens of watts of CW power at submillimeter wavelengths and ...

Prolonged interference or suppression of maternal antibodies of the humoral immune response of newly hatched chicks to active immunization has been documented; however, the immunological mechanisms responsible for such suppression are still unclear. Laying hens were immunized with dinitrophenyl-keyhole limpet hemocyanin (DNP-KLH). Purified maternal anti-DNP or non-specific IgY antibodies were t...

Since the introduction 10 years ago of the dissolution method, Dynamic Nuclear Polarization (DNP) became a widely applied and powerful technique to enhance nuclear magnetic resonance (NMR) signals of low naturally abundant, insensitive nuclear spins for analytical chemistry and biomedical research. The aim of DNP is to obtain a very high degree of polarization on the nuclei of interest in cryog...

There is little research among doctor of nursing practice (DNP) students, a fast-growing population of nurses engaged in doctoral study. In this descriptive correlational study, levels of perceived stress, sense of belonging, and the relationship between these variables were examined. The sample included 89 female, predominantly White, post-master's DNP students from a Midwest university. A sta...