Earlier studies (1, 2) from this laboratory indicated that in the dog the alkyl side chains of pentobarbital and Amytal do not undergo w oxidation but are subject to oxidation at the y-carbon atom of the amyl chains. Dogs excrete pentobarbital as two optically active diastereoisomers of ethyl(3hydroxy-1-methylbutyl)barbituric acid and Amytal as ethyl(3-hydroxyisoamyl)barbituric acid. In order t...

background : vitiligo is an acquired disease of skin that presents with depigmented patches due to lack of melanocytes in the epidermis. accumulation of toxic free radicals like hydrogen peroxide in the epidermis may be responsible for melanocytes death. since ethyl vanillate (vanillic acid ethyl ester) is a strong hydrogen peroxide scavenger, it may be effective against vitiligo. this study wa...

in this study, seasonal variations of fatty acid amounts in muscle tissues of capoeta caelestis were investigated. we have found that the ω3 contents of c. caelestis in spring, summer, autumn and winter were 17.43%, 15.29%, 17.54%, 13.63% in female and 16.96%, 19.25%, 18.66%, 14.76% in male, respectively. the amounts of ω3 polyunsaturated fatty acids were higher than those of ω6 polyunsaturated...

The aim of the study was to determine whether fatty acid ethyl esters, nonoxidative products of ethanol metabolism selectively present in organs damaged by ethanol abuse, are detectable in the serum after ethanol ingestion. Serum samples of hospital emergency room patients with positive (n = 32) and negative (n = 5) blood ethanol levels were assayed for fatty acid ethyl esters. In a separate st...

To examine the relation of cigarette smoking and alcohol consumption to serum fatty acid levels, the authors conducted a cross-sectional study of 190 men who were enrolled in the Multiple Risk Factor Intervention Trial between 1973 and 1976. After controlling for dietary fat, cholesterol, energy intake, and other potential confounders, the authors found that smoking and alcohol intake were asso...

The recent identification of myocardial metabolites of ethanol--fatty acid ethyl esters--suggests that some of the pathophysiological derangements associated with alcohol-induced heart muscle disease may be a consequence of products of myocardial ethanol metabolism. The donor of the fatty acid moiety in the formation of fatty acid ethyl esters has been identified as nonesterified fatty acid. Fa...

A novel oxalic amide-linked bisporphyrinate 1has been designed and synthesized, which shows chiral recognition ability for amino acid ethyl esters. The structure of complex 1·(D-Phe-OEt)(L-Phe-OEt) has been solved by X-ray crystallography. It reveals the following information: bisporphyrin unit adopts anti-configuration; compound 1forms 1: 2 complex with amino acid ethyl esters; one important h...

Human retinal tissue synthesized vitamin A ester through reactions associated xoith the operation of the visual cycle during light adaptation. The ester was isolated by chromatographic procedures and analyzed. The isolated vitamin A ester was found to be a mixture containing saturated and monoenoic Cn to C,3 fatty acids. The major components, comprising 90 per cent of the mixture, were vitamin ...