Bilayer tablets of Domperidone (IR) Rabeprazole (SR) were formulated for the management of gastro esophageal disorder.Immediate layer of Domperidone formulated using Tulsion T-339 as super disintegrant. For sustained release of Rabeprazole HPMC as the rate controlling polymers was used. Preformulation studies were performed prior to compression. The individual layers of the bilayer tablets were...

morphine was used as a remedy for the control of diarrhea centuries before it's sedative-analgesic effect was discovered. although several mechanisms have been proposed for the morphine-induced inhibition of gastrointestinal transit (oit), the exact mechanism has not yet been identified. on this basis the possible involvement of the dopaminergic system in morphine-induced inhibition of tra...

BACKGROUND/AIM Prolactin (PRL), a hormone produced by the pituitary gland, has multiple physiological functions, including immunoregulation. PRL can also be secreted in response to stressful stimuli. During stress, PRL has been suggested to oppose the immunosuppressive effects of inflammatory mediators. Therefore, the aim of the present study was to analyze the effects of short- and long-term h...

The aim of this study was to test whether cholinergic mechanisms regulate dopamine (DA) release from the carotid body (CB) and interact with DA D(2) autoreceptors. One hundred forty-two CBs from adult rabbits were infused in vitro in a surviving medium bubbled with O(2) (Bairam A, Marchal F, Cottet-Emard JM, Basson H, Pequignot JM, Hascoet JM, and Lahiri S. J Appl Physiol 80: 20-24, 1996). CB D...

Two simple, rapid, economical, specific, precise and accurate spectrophotometric methods have been developed for simultaneous estimation of rabeprazole sodium and domperidone maleate in their combined pharmaceutical dosage forms. Rabeprazole sodium and domperidone shows absorption maxima at 285 nm and 287 nm respectively. The first method is based on the simultaneous equations. In the simultane...

The judicious use of antiemetic treatment has made chemotherapy tolerable for a considerable number of patients.' As the dosage of antiemetic drugs is increased, however, so side effects-particularly in the central nervous system-are bound to increase in incidence and severity. We report the occurrence of seizures in four patients treated with high dose intravenous domperidone as prophylaxis ag...

Antroduodenal contractions were studied in rat preparations. Augmented duodenal contractions occurred spontaneously in coordination with antral contractions in normal and saline-pretreated preparations. The coordination did not occur when muscle layers and the myenteric plexus were transversely cut at the duodenum just anal to the gastroduodenal junction. In silent preparations, the coordinated...

Floating matrix tablets of domperidone were developed to prolong gastric residence time and thereby increased drug bioavailability. Domperidone was chosen as a model drug because it is poorly absorbed from the lower gastrointestinal tract. The tablets were prepared by wet granulation technique, using polymers such as hydroxypropylmethylcellulose K4M, carbopol 934P, and sodium alginate, either a...

Objective. To examine the association of self-efficacy, perception of milk production, and lactating women's use of medication prescribed to increase breast milk in a cohort of 18-40-year-old mothers over six months. Methods. Mothers (n = 76) attending community clinics completed the Breastfeeding Self-Efficacy Scale and the Humenick/Hill Lactation Scale, a measure of perceived milk production,...