Aim: The objective of the present research work was to develop stable extended release (ER) pellets of propranolol hydrochloride, an antihypertensive drug, for which drug release profi le is compared with reference to the multiple conventional dosage form i.e. marketed product “Inderal LA” (160 mg). Method: ER formulations were developed using fl uid bed layering and coating techniques on sugar...

The present article gives an introduction and general overview on process validation of pharmaceutical manufacturing process especially tablet manufacturing process. The principal objective of dosage form design is to achieve a predictable therapeutic response to a drug included in a formulation which is capable of large scale manufacture with reproducible product quality. Solid dosage forms in...

A simple, precise, rapid and accurate RPHPLC method was developed for the estimation of Pomalidomide (PML) in capsule dosage forms. An XTerra RP C18, (250 x 4.6 with 5 microns particle size) and the mobile phase, consisting of 0.03M KH2PO4 in water adjusting the pH-3.2 with O-Phosphoric Acid: Acetonitrile in ratio of 20:80 v/v & Acetonitrile HPLC Grade: Water HPLC Grade (50:50 v/v) was used as ...