Effects of cAMP accumulation on ATP-dependent priming and Ca(2+)-dependent fusion in Ca(2+)-regulated exocytosis were examined in antral mucous cells of guinea pigs by using video-enhanced contrast microscopy. The Ca(2+)-regulated exocytosis activated by 1 microM ACh consisted of two phases, an initial transient phase followed by a sustained phase, which were potentiated by cAMP accumulation. D...

Background: The presented phase I, first-in-human study evaluated the tolerance, pharmacokinetics, and preliminary efficacy of larotinib mesylate in patients with advanced solid tumors. Methods: Cancer were assigned to receive at 50–400 mg dose levels until disease progression or intolerance. Dose-limiting toxicities assessed during Cycles 0 1. Pharmacokinetic evaluations performed after first ...

background: pet/ct imaging using [18f]-fdg is utilized in clinical oncology for tumor detecting, staging and responding to therapy procedures. essential consideration must be taken for radiation staff due to high gamma radiation in pet/ct and cyclotron center. the aim of this study was to assess the staff exposure regarding whole body and organ dose and to evaluate environment dose in pet/ct an...

background: we have validated the monitor unit calculations from a commercially available treatment planning system (tps) for three intensity modulated radiotherapy (imrt) planning techniques for tangential breast irradiation by using ionization chamber measurements. materials and methods: treatment plans were generated for forty-two breast patients by a forward planned field in field technique...

The histochemical technique of autometallography was used in the present study to demonstrate the zonal and tubular localization of inorganic mercury in the kidneys of unilaterally nephrectomized (NPX) and sham-operated (SO) rats given either a nontoxic 0.5 mumol/kg or a toxic 2.5 mumol/kg dose of mercuric chloride 10 days after surgery. Deposits were found in the cortex and outer stripe of the...

This randomized, double-blind, placebo-controlled study assessed the safety, tolerability, and plasma-kinetic behavior of 94% pure crystalline epigallocatechin gallate (EGCG) after ten days' repeated dosing in 36 healthy male volunteers. Each of the three treatment groups consisted of 12 subjects; nine of them received oral EGCG in one dose of 200, 400, or 800 mg daily, and three received a pla...

The purpose of this study was to investigate the role of bone morphogenetic proteins (BMPs), such as BMP-7, growth factors, and cytokines, in the accumulation of superficial zone protein (SZP) in bovine articular cartilage. Calf superficial articular cartilage discs and chondrocytes were obtained for explant and monolayer culture systems, respectively. Dose- and time-dependent actions of BMP-7 ...