This is an informal personal review of the development over time of my ideas about the concentrating mechanism of the mammalian renal papilla. It had been observed that animals with a need to produce a concentrated urine have a long renal papilla. I saw the function of the long papilla in desert rodents as an elongation of the counter-current concentrating mechanism of the inner medulla. This m...

The kidney papilla contains a population of cells with several characteristics of adult stem cells, including the retention of proliferation markers during long chase periods (i.e., they are label-retaining cells [LRCs]). To determine whether the papillary LRCs generate new cells in the normal adult kidney, we examined cell proliferation throughout the kidney and found that the upper papilla is...

The dermal papilla, located in the hair follicle, expresses androgen receptor and plays an important role in hair growth. Androgen/Androgen receptor actions have been implicated in the pathogenesis of androgenetic alopecia, but the exact mechanism is not well known. Recent studies suggest that balding dermal papilla cells exhibit premature senescence, upregulation of p16(INK4a), and nuclear exp...

One of the challenges in creating an esthetic and successful dental implant restoration is the maintenance or reconstruction of the interproximal papilla. Many surgical and prosthetic techniques have been attempted to maintain or regenerate the missing interproximal papilla adjacent to dental implants. According to the literature, the results to date have been unpredictable (8-10). The papilla ...

Purpose: To report a case of double descemet membrane forming a double anterior chamber following ‘Big bubble’ DALK converted to PKP. Results: A 52-year-old man with keratoconus underwent DALK operation converted to PKP due to macro perforation of the descemet membrane. On the postoperative evaluation a remnant of the host’s descemet membrane formed a double anterior chamber. After a few months...

Hair follicle development and growth are regulated by Wnt signalling and depend on interactions between epidermal cells and a population of fibroblasts at the base of the follicle, known as the dermal papilla (DP). DP cells have a distinct gene expression signature from non-DP dermal fibroblasts. However, their origins are largely unknown. By generating chimeric mice and performing skin reconst...

Low passage cultured dermal papilla cells from adult rats stimulate complete hair follicle neogenesis when re-implanted into heterotypic skin. In contrast, cultured sheath cells are non-inductive despite sharing other behavioural characteristics (a common lineage and in situ proximity) with papilla cells. However, since sheath cells can behave inductively in amputated follicles after regenerati...

PURPOSE The aim of this study was to evaluate alterations of papilla dimensions after orthodontic closure of the diastema between maxillary central incisors. METHODS Sixty patients who had a visible diastema between maxillary central incisors that had been closed by orthodontic approximation were selected for this study. Various papilla dimensions were assessed on clinical photographs and stu...

BACKGROUND Previous studies have evaluated the presence of juxtapapillary duodenal diverticula (JPDD) and the association with pancreatobiliary disease, but not the association of the papilla with an existing JPDD. We investigated the association of different localizations of the papilla with JPDD. METHODS We studied patients in whom JPDD was detected during endoscopic retrograde cholangiopan...

background: the differences between marginal gingiva and interdental papilla may be due to variation in the molecular composition of these two different anatomical structures. the aim of this study was to evaluate the staining intensity of fibronectin in human marginal gingiva and interdental papilla. materials and methods: in a prospective analytical study, 16 healthy subjects needing crown le...