Laboratory studies have provided a foundation of knowledge regarding vehicle emissions, but questions remain regarding the relationship between on-road vehicle emissions and changes in vehicle speed and engine load that occur as driving conditions change. Light-duty vehicle emissions of CO, NO x , and NMHC were quantified as functions of vehicle speed and engine load in a California highway tun...

In contrast to classical chemical phenomenology, theory suggests that proteins may undergo downhill folding without an activation barrier under certain thermodynamic conditions. Recently, the BBL protein was proposed to fold by such a downhill scenario, but discrepancies between experimental results found in different groups argue against this. After briefly reviewing the major experimental stu...

This paper introduces and analyzes the algorithm of Parallel Genetic Alogrithm (PGA) embedded with Downhill which is applied to the optimization of continuous functions. The strategy goes this way: Subpopulation tries to locate good local minima by PGA. When a subpopulation does not progress after a certain number of generations, downhill is taken into account. Alternative downhill method (dept...

Infant rats (Rattus norvegicus) placed on a shallow incline (2 degrees, 4 degrees, or 8 degrees) oriented and moved downhill within 1 min; that is, they displayed positive geotaxis. Their downhill translocation increased with angle of inclination. A variety of possible behavioral elements (e.g., initial orientation, rotational movements, ambulatory velocities) were eliminated as explanations of...

Title: MUTATIONAL ANALYSIS OF THE DOWNHILL FOLDING PROTEIN GPW: TOWARDS TUNING STABILITY OF A MOLECULAR RHEOSTAT CANDIDATE Adam Fung, Ph.D., 2008 Directed By: Associate Professor Victor Muñoz Department of Chemistry & Biochemistry A popular convention derived from early experimental evidence of single-domain proteins pointed towards a common mechanism of achieving their native threedimensional ...

"Downhill" varices are a rare cause of acute upper gastrointestinal bleeding. Rarely these varices are reported in patients receiving hemodialysis as a complication of chronic dialysis vascular access. We present a case of acute upper gastrointestinal bleeding in an individual with end-stage renal disease receiving hemodialysis. Esophagogastroduodenoscopy revealed "downhill" varices in the uppe...

Exercise involving lengthening muscle actions, such as downhill running, results in delayed onset muscle soreness (DOMS), which may be attributable to reactive oxygen species (ROS). Although exercise causes oxidative stress, any link between ROS and DOMS remains speculative. There is emerging evidence to suggest that ROS play an important physiological role, assisting in the recovery process an...

BACKGROUND The knee is the weight-bearing joint most commonly associated with sports injuries, and therefore is most at risk of developing degenerative changes, including osteoarthritis. Skyrunners can be considered to be at risk of developing symptoms of post-traumatic osteoarthritis due to downhill running. AIM The aim of this study was to analyze the health of the knee joints of a large gr...

Few studies have examined the effects of eccentric exercise-induced muscle damage on power despite power being a key performance variable in a number of sporting events. The aim of this study was to examine changes in anaerobic power (30-second Wingate Test), isometric strength of the knee extensors and flexors, muscle soreness, and plasma creatine kinase (CK) activity following downhill runnin...

When ascending (descending) a slope, positive (negative) work must be performed to overcome changes in gravitational potential energy at the center of body mass (COM). This modifies the pendulum-like behavior of walking. The aim of this study is to analyze how energy exchange and mechanical work done vary within a step across slopes and speeds. Ten subjects walked on an instrumented treadmill a...