Oral dosage forms containing 300 mg theophylline in matrix type tablets, were prepared by direct compression method using two kinds of matrices, glycerylbehenate (hydrophobic), and (hydroxypropyl)methyl cellulose (hydrophilic). The in vitro release kinetics of these formulations were studied at pH 6.8 using the USP dissolution apparatus with the paddle assemble. The kinetics of the dissolution ...

The morphology of crystals has an appreciable impact role on the physicochemical properties of drugs. Drug properties such as flowability, dissolution, hardness and bioavailability may be affected by crystallinity behaviours of drugs. The objective of this study was to achieve an improved physicomechanical property of carbamazepine powder through recrystallization from aqueous solutions at diff...

INTRODUCTION: Dissolution is the required characterization test to evaluate new materials for transdermal drug delivery [1]. However the conventional dissolution tests, recommended by United State Pharmacopeia (USP), cannot provide results with good correlation with in vivo drug release, especially for patches that mainly depends on skin resistance to drug diffusion [2]. Other dissolution metho...

Oral bioavailability of furosemide is low (around 70%) even if a solution of 40 mg is given to healthy subjects. Sustained release formulations rendered even lower absorption of drug (one half of immediate release formulations). First pass metabolism in the stomach, slow dissolution of solid formulations in acidic media, and a narrow absorption window in the upper portion of the small intestine...

Darunavir is a nonpeptidic inhibitor of protease and primarily metabolized by cytochrome P450 3A (CYP3A) isoenzymes. It usually coadministered with low-dose ritonavir (Darunavir/r). Ritonavir an CYP3A isoenzymes pharmacologically enhances which leads to increased plasma concentrations darunavir allows for daily lower dose. Here, we have developed combination SR formulation evaluated. In vitro d...

Poly(lactic-co-glycolic acid) (PLGA) microspheres containing celecoxib were prepared via electrospraying, and the influence of three processing parameters namely flow rate, solute concentration and drug loading, on the physico-chemical properties of the particles and the drug-release profile was studied. Microspheres with diameters between 2 and 8 μm were produced and a near-monodisperse size d...

PURPOSE The aim of the present investigation was preparation and characterization of sirolimus solid dispersions by solvent evaporation technique to improve its dissolution properties. METHODS Polyvinylpyrrolidone (PVP), Poloxamer 188 and Cremophore RH40 were used to prepare the solid dispersions of sirolimus. In vitro dissolution study using USP type I apparatus, were performed in distilled ...

Purpose: Telmisartan is an angiotensin II receptor antagonist used in the management of hypertension. The solubility of Telmisartan in aqueous solutions is strongly pH-dependent. Five commercial tablets of telmisartan (40 and 80 mg) were compared with the reference formulation Micardis (Innovator brand of telmisartan molecule). Experimental: Dissolution tests were performed by employing USP typ...

Introduction In vitro dissolution testing is a critical component in the assessment of quality of a pharmaceutical product and for the validation of the development and manufacturing process of a product (1). Dissolution testing is also used to assess the rate at which a drug is released from a dosage form,as it provides a manufacturer with a rational basis on which to predict in vivo behaviour...