Experimental studies of foot-and-mouth disease (FMD) in feral swine are limited, and data for clinical manifestations and disease transmissibility are lacking. In this report, feral and domestic swine were experimentally infected with FMDV (A24-Cruzeiro), and susceptibility and virus transmission were studied. Feral swine were proved to be highly susceptible to A-24 Cruzeiro FMD virus by intrad...

BACKGROUND Accumulating clinical and preclinical evidence indicates that chronic pain is often comorbid with persistent low mood and anxiety. However, the mechanisms underlying pain-induced anxiety, such as its causality, temporal progression, and relevant neural networks are poorly understood, impeding the development of efficacious therapeutic approaches. RESULTS Here, we have identified th...

Deep Packet Inspection (DPI) systems have been increasingly performed on dedicated hardware, as an attempt to speed up the packet processing for high speed links. This is mainly caused by the current demand for CPU-intensive processing required by regular expression functions, which investigate the packet payload trying to match patterns of application signatures. This study proposes and evalua...

ZMAb is a promising treatment against Ebola virus (EBOV) disease that has been shown to protect 50% (two of four) of nonhuman primates (NHPs) when administered 2 days post-infection (dpi). To extend the treatment window and improve protection, we combined ZMAb with adenovirus-vectored interferon-α (Ad-IFN) and evaluated efficacy in EBOV-infected NHPs. Seventy-five percent (three of four) and 10...

We demonstrate the effect of two-center interference on single-photon double ionization (double photoionization DPI) of the aligned H2 molecule when it shrinks or expands from the equilibrium internuclear distance. This interference affects the first stage of the DPI process in which the primary photoelectron is ejected predominantly along the polarization axis of light and its geometrical inte...

Many recent single-shell high angular resolution diffusion imaging reconstruction techniques have been introduced to reconstruct orientation distribution functions (ODF) that only capture angular information contained in the diffusion process of water molecules. By also considering the radial part of the diffusion signal, the reconstruction of the ensemble average diffusion propagator (EAP) of ...

Desmosomes are major intercellular junctions found in association with intermediate filaments in epithelial, cardiac and arachnoidal tissue. Desmoplakins I and II (DPI and II) are highly related proteins localized in the innermost part of the desmosomal plaque and are candidates for linking intermediate filaments (IF) to the desmosomal complex. While investigators agree that DPI is present in a...

Avian Metapneumovirus (aMPV) affects both turkeys and chickens. The virus is associated with swollen head syndrome (SHS) in broilers. Most of the studies regarding aMPV have been done in turkeys. Not much is known about the pathogenesis and immune response to aMPV in broilers. Therefore, our objectives were to study the pathogenesis and immune responses of broilers experimentally infected with ...

Background/Aims The increased resistance of Helicobacter pylori to antibiotics has increased the need to develop new treatments for this bacterium. The aim of our study was to identify new drugs with anti-H. pylori activity. Methods We screened a small molecule library-the library of pharmacologically active compounds (LOPAC), which includes 1,280 pharmacologically active compounds-to identif...

The objective of this document is to describe a method of providing critical end-user notifications to web browsers, which has been deployed by Comcast, an Internet Service Provider (ISP). Such a notification system is being used to provide near-immediate notifications to customers, such as to warn them that their traffic exhibits patterns that are indicative of malware or virus infection. Ther...