Complications of mechanical ventilation increase with duration. Delayed weaning and premature weaning are both associated with increasing complications. In addition, adverse events and deterioration relating to the ventilator system could happen any time. Therefore, accurate monitoring of the patient’s respiratory condition and adjustment of ventilator settings are essential during mechanical v...

OBJECTIVES To characterize patients who received tracheostomies for airway compromise or were initiated on long-term ventilation for chronic respiratory failure in PICUs and to examine variation in the incidence of initiation, patient characteristics, and modalities across sites. DESIGN Retrospective cross-sectional analysis. SETTINGS Seventy-three North American PICUs that participated in ...

Plastics are extensively used as a material for orthoses. However, one remaining problem is the ventilation of the orthosis. This is a real problem in countries such as Japan, where it is hot and humid especially in summer. The authors have invented a new orthosis "POROPLAST", which is made of mesh plastic sheets, combined in a cross-like weave. These orthoses provide good ventilation and are v...

STUDY OBJECTIVE The validation of electrical impedance tomography (EIT) for measuring regional ventilation distribution by comparing it with single photon emission CT (SPECT) scanning. DESIGN Randomized, prospective animal study. SETTINGS Animal laboratories and nuclear medicine laboratories at a university hospital. PARTICIPANTS Twelve anesthetized and mechanically ventilated pigs. INT...

OBJECTIVE Air leak syndromes including pneumothorax, pneumomediastinum and pulmonary interstitial emphysema are frequent in neonatal period. Mechanical ventilation with positive pressure is one of the most common causes of these syndromes. The aim of this study was to evaluate predisposing factors and incidence of pneumothorax in newborns under mechanical ventilation. METHODS This descriptive...

BACKGROUND The onset of ventilation at birth decreases pulmonary vascular resistance (PVR) resulting in a large increase in pulmonary blood flow (PBF). As the large cross sectional area of the pulmonary vascular bed develops late in gestation, we have investigated whether the ventilation-induced increase in PBF is reduced in immature lungs. METHODS Surgery was performed in fetal sheep at 105 ...

Noninvasive ventilation is a clinical procedure that enables patients with chronic respiratory failure to reduce the work of breathing and to improve blood oxygenation. In order to attain such goals, the ventilation support is expected to be phase synchronized with the patient spontaneous breathing. Unfortunately, asynchrony events are not rare. In order to provide more effective ventilation sc...

Recent theories for glacial-interglacial climate transitions call on millennial climate perturbations that purged the deep sea of sequestered carbon dioxide via a "bipolar ventilation seesaw." However, the viability of this hypothesis has been contested, and robust evidence in its support is lacking. Here we present a record of North Atlantic deep-water radiocarbon ventilation, which we compare...