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The character of the intermolecular interactions in Cl2-HX (X =F, Cl and Br) complexes has been investigated by means of the second-order Möller–Plesset perturbation theory (MP2) and the density functional theory (DFT) calculations. The results show that there are two types of lowest interaction potential equilibrium structures in the interactions between Cl2 and HX: X∙∙∙Cl type geometry and hy...

introduction: drug interactions are considered as adverse effects of drugs that alter a patient’s response to an initial medication due to concurrent administration of different drugs or other substances. this study aimed to assess the role of medical education in reducing potential atorvastatin drug interactions in a teaching hospital by distributing alert cards and putting up posters in a nur...

BACKGROUND Community pharmacists play a crucial role in reducing medication related health problems and improving the patient's overall wellbeing. Evidence suggests that community pharmacist led counseling services result in a better clinical and self-reported outcome, including a higher level of satisfaction and quality of life. OBJECTIVE This study aims to document self-reported and actual ...

OBJECTIVES To evaluate health care professionals' knowledge on warfarin interactions with drugs and herbs. METHODS A self-administered questionnaire was developed to assess health care professionals' knowledge on warfarin interactions with drug and herb. Respondents were asked to classify 15 drugs that may effect on warfarin action as "enhance", "inhibit ", "no effect". The study sample invol...

Quantitative prediction of herb-drug interaction risk remains challenging. A quantitative framework to assess a potential interaction was used to evaluate a mechanism not previously tested in humans. The semipurified milk thistle product, silibinin, was selected as an exemplar herbal product inhibitor of raloxifene intestinal glucuronidation. Physiologically based pharmacokinetic (PBPK) model s...

The worldwide using of herb products and the increasing potential herb-drug interaction issue has raised enthusiasm on discovering the underlying mechanisms. Previous review indicated that the interactions may be mediated by metabolism enzymes and transporters in pharmacokinetic pathways. On the other hand, an increasing number of studies found that genetic variations showed some influence on h...

1 Identify the mechanism of grapefruit juice-drug interactions and drugs involved with significant grapefruit-drug interactions. 2 Describe potential effects of grapefruit juice-drug interactions.. 3 Discuss medications that may be affected and degree of risk associated with common interacting medications.. 4 Identify effective alternative medications that do not interact (for patients who do n...

There is an increase in population of elderly above the age of 65. As age advances, more diseases develop resulting in use of more medications. Physiological changes, alterations in homeostatic regulation and diseases modify pharmacokinetics and drug response in older patients. The risk for drug interactions and drug-related problems increases along with multiple medications. Periodic evaluatio...

Purpose Individuals using herbal medicines concomitantly with prescription drugs are at risk of harms due to herb-drug interactions. As part of a prospective active surveillance study to identify natural health product harms, a tool to identify herb-drug interactions was created for clinician use. Such tools require regular updating to remain clinically relevant. Our objective was to review the...