Gastroretentive dosage forms (GRDF) has received significant interest in the past few decades as they can improve the limitation of most conventional and oral controlled release drug delivery system related to fast gastric-emptying time. An optimum GRDF system can be defined as a system which retains in the stomach for a sufficient time interval against all the physiological barriers, releases ...

Vaginitis is mostly caused by Trichomonas vaginalis leading to mild to severe infections in the vaginal mucosa. The treatment for this disease can be initiated with the help of antimicrobial and antifungal agents in various dosage forms. Novel dosage forms have gained prior significance in recent formulation researches due to their inevitable controlled drug release mechanism and site specific ...

Clinical studies have shown that circadian patterns influence the pharmacokinetics of certain drugs used in the treatment of different diseases. For such drugs, the bioavailability is influenced by the time of administration. The objective of this study was to investigate differences in the pharmacokinetic patterns between a pulsatile drug delivery system using a pulsatile capsule, pure active ...

In patients battling cancer, many aspects of antimicrobial treatment become more complex, and standard antimicrobial regimens may be inadequate. Various pathophysiological changes in critically ill patients with cancer significantly affect the pharmacokinetics (PK) of antimicrobials. In an unacceptably high percentage of these patients, variability of relevant PK parameters results in inadequat...

Ophthalmic drug delivery is one of the most interesting and challenging endeavors facing the pharmaceutical companies in the market. In ophthalmic formulation to the eye like solutions, suspensions, and ointments are available in the market shows drawbacks such as increased precorneal elimination, high variability in efficiency, and blurred vision. The major problem associated with the conventi...

the objective of present research was to design, evaluate and compare drug release from two different dosage forms in pulsatile drug delivery system (dds) for metoprolol tartarate (mt) as tablet and capsule. pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery ...

The desire of improved palatability in orally administered products has prompted the development of numerous formulations with improved performance and acceptability. Orally disintegrating tablets are an emerging trend in novel drug delivery system and have received ever-increasing demand during the last few decades. The field has become a rapidly growing area in the pharmaceutical industry and...

For most drugs, initial dosage for different individuals is associated with many factors, such as weight and age. If drug blood concentrations can be measured, the dosage of the drug may be adjusted to the blood value to get an acceptable range. With regards to immunosuppressive drugs, like tacrolimus, dose that is too low could cause organ rejection, and a dose that is too high could cause tox...

INTRODUCTION Dissolution testing is an in vitro technique of great importance in formulation and development of pharmaceutical dosage forms,as it can be used as a substitute for in vivo studies under strictly defined and specified conditions (1). For the comparison of in vitro dissolution data and for use of such data for in vivo bioequivalence testing and in vitro-in vivo correlations (IVIVC) ...