the goal of this research is to determine the feasibility of loading rifampin into mesoporous silica nanoparticles. rifampin was selected as a model lipophilic molecule since it is a well-documented and much used anti tuberculosis drug. the mesoporous silica nanoparticles were prepared by using tetraethyl ortho silicate and cetyltrimethyl ammonium bromide (as surfactant); the prepared nanoparti...

the main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of methocel® k15, ethocel® standard 7fp premium, eudragit ® rs100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. risperidone floating tablets were formulated by wet granulati...

to improve drug selectivity toward target cells, one interesting approach for drug delivery is to use polymer nanoparticles. a two-layered oniom becke3- lyp: uff calculation was carried out to study the structural and thermodynamic properties of the interaction between acetamide derivatives and the pca-peg-pca copolymers. the interaction enthalpies and the gibbs free energies between acetamide ...

background : following establishment of iranian adverse drug reaction (adr) monitoring  center  in  1997, adr  committees  were  established  in  all  hospitals  of mazandaran province of iran. clinical pharmacists from mazandaran university of medical sciences have been involved with these committees since 2007. the aim of this study was to compare the results of the pharmacovigilance system b...

drug utilization evaluation (due) is an effective program to identify variability in drug use and to support interventions that will improve patient outcomes. the appropriate use of enoxaparin, a low molecular weight heparin (lmwh), which is widely used as curative or preventive treatment of thromboembolic disorders was assessed in the study. a prospective due was carried out at masih daneshvar...

conclusions globally, interventions that comprise evidence-based prevention, care and treatment of substance use disorders in young adults are vital to reduce the transmission of hiv infection and promote good clinical outcomes for young adults at-risk for living with hiv. context young adults comprise roughly one-quarter of the global population and are at the developmental stage where persona...

conclusions this study represented an increasing rate of mdr p. aeruginosa in burn and wound samples. efflux mexab genes were detected in all mdr and pdr strains. the p. aeruginosa strain isolated from burn cases showed higher drug resistance and pdr resistance was only noted in a burn sample. materials and methods one-hundred and fifty p. aeruginosa were isolated from burn and wound infections...

aims: cholera is an acute diarrheal disease that can lead to severe dehydration and death. antibiotic resistance is a big challenge in infective disease like cholera. the present study aimed to understand the characteristics and trends of antibiotic resistance of v. cholerae isolations in and around kashan, iran. instrument & methods: in this descriptive cross-sectional study, samples were gath...

with the aim of obtaining information about drug-drug interaction (ddi) between acetaminophen and some of antidepressant drugs (fluoxetine, sertraline and nortriptyline), in the present work we studied the electrochemical oxidation of acetaminophen (paracetamol) in the presence of these drugs by means of cyclic voltammetry and controlled-potential coulometry. the reaction between n-acetyl-p-ben...