Michael A. Yokell, ScB, Traci C. Green, MSc, PhD, Sarah Bowman, MPH, Michelle McKenzie, MPH, and Josiah D. Rich, MD, MPH  introduCtion Opioid overdose is a major public health concern that affects a diverse group of individuals across all categories of race, class, and geography. Overdose is the leading cause of adult accidental death in Rhode Island, making our state one of only 16 where over...

background: most drug overdoses are due to suicidal attempts. this study was designed to analyze the risks and risk factors of poisoned patients with repeated suicidal attempt in iran. methods: this case-control study was conducted at loghman hakim hospital, tehran, iran, during april to may 2008. eighty-seven patients who were admitted due to drug overdose with loss of consciousness were enrol...

Metabolomics approaches have enabled the study of new mechanisms of liver injury in experimental models of drug toxicity. Disruption of bile acid homeostasis is a known mechanism of drug induced liver injury. The relationship of individual bile acids to indicators of oxidative drug metabolism (acetaminophen protein adducts) and liver injury was examined in children with acetaminophen overdose, ...

2. Ambre, J. J., and Fischer, L. J., Identification and activity of the hydroxy metabolite which accumulates in the plasma of humans intoxicated with glutethimide. Drug Metab. Disposition (in press). 3. Gold, M., Tassoni, E., Etzl, M., and Mathew, G., Concentration of glutethimide and associated compounds in human serum and cerebrospinal fluid after drug overdose. Clin. Chem. 20, 195 (1974). 4....

OBJECTIVES To describe the circumstances surrounding recent heroin overdose among a sample of heroin overdose survivors and the links to their knowledge of overdose risk. METHODS A cross-sectional survey of 257 recent non-fatal heroin overdose survivors was undertaken to examine self-reported knowledge of overdose risk reduction strategies, behaviour in the 12 h prior to overdose and attribut...

BACKGROUND Gamma-hydroxybutyrate (GHB) and gamma-butyrolactone (GBL) have been profiled as 'party drugs' used mainly at dance parties and in nightclubs on weekend nights. The purpose of this study was to examine the frequency of injecting drug use among GHB/GBL overdose patients and whether there are temporal differences in the occurrence of GHB/GBL overdoses of injecting drug and recreational ...

COVID-19 is compounding opioid use disorder throughout the United States. While recent commentaries provide useful policy recommendations, few studies examine intersection of responses and patterns overdose. We overdoses prior to following Pennsylvania stay-at-home order implemented on April 1, 2020. Using data from Overdose Information Network, we measure change in monthly incidents opioid-rel...