The COVID-19 coronavirus, which primarily affects the lungs, is source of disease known as SARS-CoV-2. According to “Smoking and COVID-19: a scoping review,” about 32% smokers had severe case pneumonia at their admission time 15% non-smokers this pneumonia. We were able determine genes expressed differently in each group by comparing expression gene transcriptomic datasets patients, smokers, he...

Institute for Computer Science Humboldt-Universität zu Berlin Unter den Linden 6 10099 Berlin Germany Fraunhofer Institute for Algorithms and Scientific Computing (SCAI) Schloss Birlinghoven 53754 Sankt Augustin Germany Bonn-Aachen Center for Information Technology (B-IT) Dahlmannstraße 2 53113 Bonn Germany {tbobic,klinger,hofmann-apitius}@scai.fraunhofer.de {thomas,leser}@informatik.hu-berlin....

Photoaffinity labeling followed by tandem mass spectrometry is an often used strategy to identify protein targets of small-molecule drugs or drug candidates, which, under ideal conditions, enables the identification actual binding site. In case bioactive peptides, however, identifying distinct site hampered because complex fragmentation patterns during spectrometry. We here report development a...

We conducted a study to identify circular RNAs associated with invasive non-functioning pituitary adenomas and chemoresistance, as well construct competitive endogenous RNA network. performed expression profiling of 10 specimens using sequencing identified 37 differentially expressed RNAs, which were validated real-time quantitative polymerase chain reaction. also detected 26 microRNAs 388 mess...