نتایج جستجو برای: drug resistancsequence homology
تعداد نتایج: 635775 فیلتر نتایج به سال:
We construct a stable homotopy refinement of quantum annular homology, link homology theory introduced by Beliakova, Putyra and Wehrli. For each $r\geq 2$ we associate to an $L$ naive $\mathbb{Z}/r\mathbb{Z}$-equivariant spectrum whose cohomology is isomorphic the as modules over $\mathbb{Z}[\mathbb{Z}/r\mathbb{Z}]$. The construction relies on equivariant version Burnside category approach Laws...
We give a new proof of the non-triviality wheel graph homology classes using higher operations on Lie and derived version Koszul duality for modular operads.
Clostridium perfringens is an anaerobic pathogen known to cause vast number of diseases in mammals and birds. Various toxins and hydrolysing enzymes released by the organism are responsible for the necrosis of soft tissues. Due to serious safety issues associated with current vaccines against C. perfringens, there is a need for new drug or vaccine targets. C. perfringens is extremely dependent ...
here, we report analysis of in vitro and in vivo drug release from an in situ formulation consisting of triamcinolone acetonide (tr) and poly(d,l-lactide-co-glycolide) (plga) and the additives glycofurol and hydroxyapatite nanoparticles (ha). we found that these additives enhanced drug release rate. we used the taguchi method to predict optimum formulation variables to minimise the initial burs...
Selegiline was used as a model compound in a project aimed at comparing, evaluating, and integrating different in vitro approaches for the prediction of cytochrome p450 (p450)-catalyzed hepatic drug metabolism in humans (EUROCYP). Metabolic predictions were generated using homology modeling, cDNA-expressed p450 enzymes, human liver microsomes, primary cultured human hepatocytes, and precision-c...
A mutation was constructed in the CAP homology domain of yeast topoisomerase II that resulted in hypersensitivity to the intercalating agent N-[4-(9-acridinylamino)-3-methoxy-phenyl]methanesulfonamide and the fluoroquinolone 6, 8-difluoro-7-(4'-hydroxyphenyl)-1-cyclopropyl-4-quinolone-3-carboxyli c acid, but not to etoposide. This mutation, which changes threonine at position 744 to proline, al...
We created SynSysNet, available online at http://bioinformatics.charite.de/synsysnet, to provide a platform that creates a comprehensive 4D network of synaptic interactions. Neuronal synapses are fundamental structures linking nerve cells in the brain and they are responsible for neuronal communication and information processing. These processes are dynamically regulated by a network of protein...
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