The epidemic of drug-resistant tuberculosis (DR-TB) is a public health emergency that threatens to destabilise global TB control. Although TB incidence and mortality are decreasing in several parts of the world, the overall prevalence of multidrug-resistant tuberculosis (MDR-TB) is increasing in many high-burden countries, particularly in Africa.[1] World Health Organization (WHO) statistics sh...

The knowledge of the prevalence of drug resistant tuberculosis in the population is important information about the epidemiology of the disease in the country. In Poland, the incidences of drug-resistant tuberculosis have been monitored since the early years of chemotherapy. In the period from 1997 to 2012 were four prospective studies covering the whole country. The aim of this study was to de...

The goal of this study was to evaluate the prevalence of first-line anti-tuberculosis drug resistance and risk factors associated with multidrug-resistant tuberculosis (MDR TB) among young soldiers in the Korean military, which has a strict tuberculosis control program. All patients with culture-confirmed pulmonary tuberculosis during their service at the Armed Forces Capital Hospital from Janu...

We expanded second-line tuberculosis (TB) drug susceptibility testing for extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa. Of 19 patients with extensively drug-resistant TB identified during February 2008-April 2009, 13 (68%) had isolates resistant to all 8 drugs tested. This resistance leaves no effective treatment with available drugs in South Africa.

Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis have emerged as important infections in South Africa among patients infected with human immunodeficiency virus (HIV). In the face of this new epidemic, South Africa must rededicate itself to the task of tuberculosis control and treatment with a rapid, multifaceted approach. Priorities include expansion of second-line t...

Background: Drug-Resistant Tuberculosis (DR-TB) is one of the major public health issues globally. Zambia highly burdened by TB and multi-drug resistant TB. In this study, sputum samples obtained from new previously treated cases were examined for drug-resistant Mycobacterium tuberculosis (MTB). Methods: Sputum specimens processed using N-acetyl-L-cysteine-sodium hydroxide method, stained fluor...

References 1 World Health Organization. Companion Handbook to the WHO Guidelines for Programmatic Management of Drug Resistant Tuberculosis. WHO/HTM/TB/2014.11. Geneva, WHO, 2014. 2 Cox HS, Furin J, Mitnick CD, et al. The need to accelerate access to new drugs for multidrug-resistant tuberculosis. Bull World Health Organ 2015; 93: 491–497. 3 Isaakidis P, Cox HS, Varghese B, et al. Ambulatory mu...

5. Jeon CY, Hwang SH, Min JH, Prevots DR, Goldfeder LC, Lee H, et al. Extensively drug-resistant tuberculosis in South Korea: risk factors and treatment outcomes among patients at a tertiary referral hospital. Clin Infect Dis. 2008;46:42–9. DOI: 10.1086/524017 6. Yu MC, Wu MH, Jou R. Extensively drug-resistant tuberculosis, Taiwan. Emerg Infect Dis. 2008;14:849–50. DOI: 10.3201/eid1405.071398 7...