Macrophages are the most abundant immune cell within the ovary. Their dynamic distribution throughout the ovarian cycle and heterogenic array of functions suggest the involvement in various ovarian processes, but their functional role has yet to be fully established. The aim was to induce conditional macrophage ablation to elucidate the putative role of macrophages in maintaining the integrity ...

This study's aim was to evaluate the stress distribution in a mandibular implant-supported prosthesis and peri-implant bone considering implant quantity, diameter and position using linear 3-D finite element analysis. Models of an anterior jaw comprised 4 groups according to implant quantity, diameter, and position: control group C, 5 regular implants; R, 3 regular implants; W, 3 wide implants;...

We developed a transgenic mouse to permit conditional and selective ablation of hair cells in the adult mouse utricle by inserting the human diphtheria toxin receptor (DTR) gene into the Pou4f3 gene, which encodes a hair cell-specific transcription factor. In adult wild-type mice, administration of diphtheria toxin (DT) caused no significant hair cell loss. In adult Pou4f3(+/DTR) mice, DT treat...

Inflammatory bowel disease (IBD) including Crohn's disease (CD) and ulcerative colitis is a relapsing-remitting illness. Patients with long-standing extensive colitis are easy to develop colorectal cancer (CRC). The increasing incidence of IBD and a substantial increase in the risk of CRC make the necessity to pay more attention on the regulation of inflammation especially by specific macrophag...

Laparoscopic proximal gastrectomy (LPG) is theoretically a superior choice of minimally-invasive surgery and function-preserving surgery for the treatment of proximal early gastric cancer (EGC) over procedures such as laparoscopic total gastrectomy (LTG), open total gastrectomy (OTG) and open proximal gastrectomy (OPG). However, LPG and OPG are not popular surgical options due to three main con...

The biological role of Langerin+ dendritic cells (DCs) such as Langerhans cells and a subset of dermal DCs (dDCs) in adaptive immunity against cutaneous pathogens remains enigmatic. Thus, we analyzed the impact of Langerin+ DCs in adaptive T cell-mediated immunity toward Leishmania major parasites in a Lang-DTR mouse model that allows conditional diphtheria toxin (DT)-induced ablation of Langer...

The increased integrations of intermittent renewable energy sources into power systems cause more grid congestions and therefore system operators need advanced control to relieve this pressure. dynamic thermal rating (DTR) is able increase the constraint subsequently maximum loading existing lines. This achieved through real-time considerations weather data it usually much higher than tradition...

This study was conducted to determine whether selecting an optimum sowing date couldimprove yield. The experiment consisted of sowing a film-covered, drip-irrigated cotton field onfour sowing dates from April to May in 2011-2012 at the Agrometeorological ExperimentalStation of Wulanwusu, which was in an arid region of north-western China. Late sowing datesproduced less yield and water-use effic...

Nowadays, transformers can be operated close to their thermal limits. The state of the art in transformer limits are Dynamic Thermal Rating (DTR). DTR based on two temperature limits: either a design or maximal-permissible temperature. However, many papers estimate with only. Therefore, true is still underestimated since limit ignored as well current (in some papers). Moreover, rely conservativ...