Mitochondria heavily depend on the coordinated expression of both mitochondrial and nuclear genomes because some of their most significant activities are held by multi-subunit complexes composed of both mitochondrial and nuclear encoded proteins. Thus, precise communication and signaling pathways are believed to exist between the two compartments. Proteins dual localized to both mitochondria an...

in this note we consider the notion of intuitionistic fuzzy (weak) dual hyper k-ideals and obtain related results. then we classify this notion according to level sets. after that we determine the relationships between intuitionistic fuzzy (weak) dual hyper k-ideals and intuitionistic fuzzy (weak) hyper k-ideals. finally, we define the notion of the product of two intuitionistic fuzzy (weak) du...

Colorectal cancer has been one of the most common cancers in the worldwide. Poor patient compliance and serious side effects often associated with conventional therapy (e.g. surgery, radiation, and chemotherapy). Gene therapy may be an alternative strategy. Herein, we developed a dual-targeting nanoparticle with excellent gene transfection efficiency for gene therapy of peritoneal metastasis of...

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Arabidopsis thaliana calcineurin B-like proteins (CBLs) interact specifically with a group of CBL-interacting protein kinases (CIPKs). CBL/CIPK complexes phosphorylate target proteins at the plasma membrane. Here, we report that dual lipid modification is required for CBL1 function and for localization of this calcium sensor at the plasma membrane. First, myristoylation targets CBL1 to the endo...

Since the introduction of inflation targeting, inflation expectations have become firmly anchored at target and there has been a flattening of the Phillips curve. These changes mean that a “divine coincidence” between headline inflation and output-gap stabilization is less apparent than when inflation targeting was introduced. This has led some to call for a fundamental reengineering of inflati...

Materials and methods Triplebodies are a new class of antibody derivatives developed by our team, which consist of 3 antigen-binding domains carried in a single polypeptide chain. The distal domains bind 2 targets on the same cancer cell, the central domain binds a trigger molecule on an effector cell. If the 2 targets on the cancer cell are different, the triplebody is said to be ‘dual-targeti...