Helicobacter pylori is an important risk factor for gastric cancer, gastric ulcer, and duodenal ulcer, yet most infected persons do not develop disease. We examined two correlates of acquisition age, sibship size and birth order, to evaluate the hypothesis that early life acquisition of H. pylori is a risk factor for the development of these illnesses. In earlier nested case-control studies of ...

Basal and pentagastrin stimulated gastric secretion was measured in seven patients with duodenal, and six with gastric ulcers before and after four weeks' treatment with colloidal bismuth subcitrate (as De-Nol), one tablet four times a day. Each duodenal and all but one of the gastric ulcers healed. After De-Nol there were no significant changes in basal, or pentagastrin stimulated volume, acid...

BACKGROUND Although overall admission rates for peptic ulcer in England declined from the 1950s up until the mid 1980s, perforations among older women increased, possibly due to increasing use of non-steroidal anti-inflammatory drugs (NSAID). Since then, proton pump inhibitors, antibiotic treatment for Helicobacter pylori, low dose aspirin, and selective serotonin reuptake inhibitors (SSRI) hav...

In order to identify the risk factors affecting the healing of duodenal ulcer, a clinical trial with effective dose of antacid was carried out in 53 patients. Duration of ulcer history, number of relapses, duration of the last and present relapse, number, duration and severity of pain attacks in the present ulcer relapse, pain radiation to back, vomiting, appetite, smoking habit, intake of anal...

A conceivable concept for the development of duodenal ulcers in Helicobacter pylori (H. pylori) infected subjects is presented in this chapter. The concept includes an explanation of the fact that only a minority of all H. pylori-infected subjects will develop a duodenal ulcer. Helicobacter pylori infection of the antrum induces a hypersecretion of gastric acid secretion, giving rise to gastric...

Eighty patients with duodenal ulcer were randomly allocated to treatment with tripotassium dicitrato bismuthate (TDB) tablets or cimetidine. Ulcers healed in 78% of patients treated with TDB and in 74% treated with cimetidine, supporting previous observations that the efficacy of these two agents is similar. Duodenal ulcer recurred in 43% of patients in the 12 months after treatment with TDB an...

500 cases of Esophago-Gastroscopy were evaluated at the Shahid Moddares teaching and research medical center. Endoscopic diagnosis were:  38% Gastritis, 24% Duodenal Ulcer, 8% Esophageal Carcinoma, 6% Gastric Carcinoma, 6% Gastric Ulcer, 6% Hiatal Hernia, 3% Esophageal Varises.  In 68% of these cases Gastroscopy findings were in Agreement with Radiology reports. 

Dose-response curves were obtained from forty adult male control subjects and forty patients with duodenal ulcer by administering 1-6, 2-0, 2-4, 2-8, 3-2mg doses of histamine acid phosphate (HAP) subcutaneously. The results showed that the minimal dose of HAP for MAO for patients with duodenal ulcer was significantly greater than that required for control subjects. A significant positive correl...

The relationship between the secretion of pepsin 1 (the most electronegative of the pepsins), and the smoking habits of 219 patients has been investigated. Significantly more cigarette smokers with peptic ulceration (72.5%) secreted pepsin 1 in greater than trace amounts after pentagastrin or histamine than did non-smokers with ulceration (51.2%). Differences of a similar order were found for m...

Dose-response curves were obtained from forty male control subjects and forty male patients with duodenal ulcer from India on the subcutaneous histamine test. The body weight and maximal acid output (MAO) showed a positive correlation just significant at the 5%o level in control subjects (P=0 05) but not in patients with duodenal ulcer. The values of MAO on dose-response curves are comparable i...