نتایج جستجو برای: durable resistance
تعداد نتایج: 387540 فیلتر نتایج به سال:
High-dose bolus interleukin 2 (IL-2) was granted Food and Drug Administration approval based on its ability to produce durable complete responses in a small number of patients with metastatic renal cell carcinoma. Results from randomized phase 3 trials suggest that regimens involving lower doses of IL-2, either alone or in combination with IFN, produce fewer tumor regressions of less overall qu...
Stripe (yellow) rust, caused by Puccinia striiformis f. sp. tritici (Pst), is one of the most destructive diseases of wheat worldwide. Planting resistant cultivars is an effective way to control this disease, but race-specific resistance can be overcome quickly due to the rapid evolving Pst population. Studying the pathogenicity mechanisms is critical for understanding how Pst virulence changes...
The need to protect external walls from excess moisture improve heat-shielding properties is an urgent task. If the outer wall created expanded clay concrete blocks, then most interesting are blocks by layer-by-layer moulding, in which each layer can have its own given density. In such has coefficients of thermal conductivity and vapor permeability, allows you select required heat transfer resi...
Chordal replacement with expanded polytetrafluoroethylene (ePTFE) sutures has proven to be a simple, versatile, and durable technique for the treatment of prolapsed cusps causing mitral valve regurgitation. ePTFE is known for its strong resistance to tension, and is judged to be unbreakable under physiological conditions. Herein are reported two cases of rupture of synthetic chordae tendineae; ...
The brown planthopper (BPH) is the most serious insect pest of rice in Asia. The indica rice cultivar ADR52 carries two BPH resistance genes, BPH26 (brown planthopper resistance 26) and BPH25. Map-based cloning of BPH26 revealed that BPH26 encodes a coiled-coil-nucleotide-binding-site-leucine-rich repeat (CC-NBS-LRR) protein. BPH26 mediated sucking inhibition in the phloem sieve element. BPH26 ...
The therapeutic landscape of melanoma is improving rapidly. Targeted inhibitors show promising results, but drug resistance often limits durable clinical responses. There is a need for in vivo systems that allow for mechanistic drug resistance studies and (combinatorial) treatment optimization. Therefore, we established a large collection of patient-derived xenografts (PDXs), derived from BRAF(...
Imatinib mesylate is a selective Bcr-Abl kinase inhibitor, effective in the treatment of chronic myelogenous leukemia. Most patients in chronic phase maintain durable responses; however, many in blast crisis fail to respond, or relapse quickly. Kinase domain mutations are the most commonly identified mechanism associated with relapse. Many of these mutations decrease the sensitivity of the Abl ...
Secreted proteins coded by parasitism genes expressed in esophageal gland cells mediate infection and parasitism of plants by root-knot nematodes. An essential parasitism gene, designated as 16D10, encodes a conserved root-knot nematode secretory peptide that stimulates root growth and functions as a ligand for a plant transcription factor. Plants were engineered to silence this parasitism gene...
Since the introduction of highly active antiretroviral therapy in the mid-1990s, antiretroviral therapy (ART) options have expanded considerably to include simpler, safer, and more tolerable regimens. This has included new options for initial regimens for treatment-naive patients as well as regimens for treatment-experienced patients with extensive drug resistance. Current regimen options are e...
Sclerospora graminicola pathogen is the most important biotic production constraints of pearl millet in India, Africa and other parts of the world. We report a de novo whole genome assembly and analysis of pathotype 1, one of the most virulent pathotypes of S. graminicola from India. The draft genome assembly contained 299,901,251 bp with 65,404 genes. This study may help understand the evoluti...
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