BACKGROUND AND PURPOSE Estimates of blood volume and volume transfer constant are parameters commonly used to characterize hemodynamic properties of brain lesions. The purposes of this study were to compare values of volume transfer constant and estimates of blood volume in high-grade gliomas on a pixel-by-pixel basis to comprehend whether they provide different information and to compare estim...

in this paper, we propose and investigate distribution of intravascular and extravascular extracellular volume fractions (dieef) as a noninvasive biomarker for neovascularization assessment by dynamic contrast‑enhanced magnetic resonance imaging (dce‑mri). a generalized two‑compartment exchange model (g2cxm) that uniformly includes the patlak model, tofts model, extended tofts model, and recent...

Compared to gold-standard measurements of cerebral perfusion with positron emission tomography using H(2)[(15)O] tracers, measurements with dynamic susceptibility contrast MR are more accessible, less expensive, and less invasive. However, existing methods for analyzing and interpreting data from dynamic susceptibility contrast MR have characteristic disadvantages that include sensitivity to in...

Relative cerebral blood volume (rCBV) is a magnetic resonance imaging biomarker that is used to differentiate progression from pseudoprogression in patients with glioblastoma multiforme, the most common primary brain tumor. However, calculated rCBV depends considerably on the software used. Automating all steps required for rCBV calculation is important, as user interaction can lead to increase...

OBJECTIVES Angiogenesis and anti-angiogenetic medications play an important role in progression and therapy of glioblastoma. In this context, in vivo characterization of the blood-brain-barrier and tumor vascularization may be important for individual prognosis and therapy optimization. METHODS We analyzed perfusion and capillary permeability of C6-gliomas in rats at different stages of tumor...