Darier's disease is a skin disorder characterized by multiple eruptions of hyperkeratosis or crusted papules at seborrheic areas with histologic acantholysis and dyskeratosis. It is caused by mutations in a single gene, being ATP2A2 and that is expressed in the skin and brain. The cooccurrence of various neurologic and psychiatric diseases with Darier's disease has been reported frequently in l...

Galli-Galli disease is a rare genodermatosis currently regarded as an acantholytic variant of Dowling-Degos disease. The 2 diseases have the same clinical features: reticular hyperpigmented macules in the great skin folds, erythematous scaly papules and plaques, comedo-like lesions, and pitted perioral scars, and the only differentiating characteristic is the histological finding of acantholysi...

Darier's disease, also known as keratosis follicularis or dyskeratosis follicularis, is a rare disorder of keratinization. It is an autosomal dominant genodermatosis with high penetrance and variable expressivity. Its manifestation appears as hyperkeratotic papules, primarily affecting seborrheic areas on the head, neck, and thorax and less frequently on the oral mucosa. When oral manifestation...

Squamous cell carcinoma (SCC) is the second most common type of skin cancer, with basal cell carcinoma being the most common. However, some argue that an actinic keratosis should be considered as an SCC that is superficial.1 If so, then SCC could be considered the most common type of skin cancer. The tumor typically appears as a papule or nodule, with varying degrees of hyperkeratosis and ulcer...

Background/Aims The development of programmed cell death-1 (PD-1) inhibitors has greatly improved patient outcomes in the treatment of a variety of advanced malignancies. These novel immunotherapies are not without adverse effects, the most common of which are dermatologic. Methods We report our experience with an atypical erythema multiforme-like eruption in a patient with primary central ne...

squamous cell carcinoma (scc) is a malignant tumor of epidermal cells in which the cells show differentiation to keratinocytes and is common in the horses, cattle, cats and dogs but is uncommon in the sheep. this communication describes a case of cutaneous squamous cell carcinoma (scc) in a 5-year-old ewe. the tumor mass located on lumbar back and histological evaluation of biopsy sample reveal...