The aim of this study was to characterize the effect of typhoid fever on pharmacokinetic parameters of levofloxacin (LF) and compare the pharmacokinetic parameters of the said antibiotic in healthy human volunteers and patients with typhoid fever. Total of 12 subjects were divided into two groups “A” (healthy volunteers) and “B” (typhoid patients). Single oral dose of LF 500 mg was given and 5 ...

The essential oils (EOs) of Telekia speciosa, a perennial plant native to southeastern Europe and Asia Minor, were analyzed for their composition biological properties. T. speciosa is an invasive in Poland; however, its beauty prompts gardeners cultivate the plants. serves as valuable source nectar pollen honey bees. Our results revealed more than 150 compounds flower, leaf, root EOs. Major con...

The antimicrobial activity of different extracts of Piper regnellii was evaluated through the broth microdilution assay. The leaves, roots and stems extracts presented a good activity against Staphylococcus aureus and Bacillus subtilis with minimal inhibitory concentration (MIC) between 31.25 62.5 μg/ml. Although the differences were not significant, the leaves hydroalcoholic extract tended to ...

Abstract Background Medicinal herbs in Malaysia like Clinacanthus nutans (CN) traditionally are used the treatment of various diseases and cancers. The present research was conducted to determine effects C. leaf different solvent extracts on human breast cancer cell lines (MCF-7). antiproliferative growth survival dichloromethane CN (CNDCM), as well short- long-term through metastasis, apoptosi...

Acute acidosis was induced in sheep, and gastrointestinal permeability was assessed by using lactulose as a permeability marker. Metabolism was evaluated by monitoring blood metabolites. Four rams (72.5 ± 4.6 kg BW) were used in a 2 × 2 changeover design experiment. The experimental period lasted 96 h from -24 to 72 h. After 24 h of fasting (from -24 to 0 h) for both controls and acidosis-induc...

Leishmania donovani is an obligatory intracellular digenetic parasite transmitted by insects, causing serious global health problems as it endemic to most developing countries. Extensive use of antimony compounds drugs poses high toxicity and cost; therefore, herbal medicine has identified a position. This study explored the developmental biochemical characteristics L. promastigote effect ethan...

BACKGROUND The interrelationship between human airway epithelium and complement proteins may affect airway defence, airway function, and airway epithelial integrity. A study was undertaken to determine (1) whether unstimulated human bronchial epithelium generates complement proteins and expresses cell membrane complement inhibitory proteins (CIP) and (2) whether stimulation by proinflammatory c...

The aim of this study was to characterize the effect of typhoid fever on pharmacokinetic parameters of levofloxacin (LF) and compare the pharmacokinetic parameters of the said antibiotic in healthy human volunteers and patients with typhoid fever. Total of 12 subjects were divided into two groups “A” (healthy volunteers) and “B” (typhoid patients). Single oral dose of LF 500 mg was given and 5 ...

The green seaweed Enteromorpha prolifera was used as a feedstock for the production of enzymatic hydrolysate using cellulase. The selection of the conditions for enzymatic hydrolysis of the biomass was carried out for different enzyme doses and incubation periods. The obtained extract was examined in terms of its multielemental composition, content of polyphenols and antibacterial properties (t...

The object of this study was to assess the effects of the inflammatory cytokine interleukin 1β (IL-1β) (0.01–1.0 ng/ml) on the activity of catalase (CAT), superoxide dismutase (SOD) and the level o f glutathione (GSH), all being antioxidant mechanisms, in human peritoneal mesothelial cells (HPMC) in in vitro c ulture. HPMC were obtained from the omenta of nonuremic donors. The activity of the a...