نتایج جستجو برای: e10 e31
تعداد نتایج: 1370 فیلتر نتایج به سال:
AIMS The importance of pleiotropic effects of statins on endothelial function and inflammatory markers was investigated in patients with dysglycaemia and coronary artery disease (CAD). METHODS AND RESULTS Thirty-nine patients were randomized to simvastatin 80 mg daily (S80; n = 20) or ezetimibe 10 mg and simvastatin 10 mg daily (E10/S10; n = 19) for 6 weeks, aiming at similar cholesterol redu...
K-ras is frequently mutated in lung adenocarcinomas. Recent discovery that wild-type K-ras is tumor suppressive in the lung raises a question: how is mutant K-ras aggressively oncogenic? We hypothesized that mutant K-ras might lead to generation of reactive oxygen species (ROS) and DNA damage, contributing to malignant transformation. We stably transfected human mutant K-ras(V12) into non-trans...
در این پایان نامه ابتدا به بررسی خواص صفحات مطلق با رهیافت اصل موضوعی می پردازیم. سپس زیر گروه ویژه ای از خود ریختی های آن به نام حرکت ها را معرفی کرده و مجموعه ی حرکت های سره را مورد مطالعه قرار می دهیم. در ادامه به هر صفحه ی مطلق مانند یک گروه مرتب جابجایی نظیر می شود که w,+ یک زیر گروه از k- لوپ (e, +) نظیر صفحه ی مطلق است. به کمک رابطه ی ترتبیب روی صفحه ی مطلق مفاهیمی چون نیم خط، زاویه، ان...
MALT B cell lymphomas with t(1;14)(p22;q32) showed a recurrent breakpoint upstream of the promoter of a novel gene, Bcl10. Bcl10 is a cellular homolog of the equine herpesvirus-2 E10 gene: both contain an amino-terminal caspase recruitment domain (CARD) homologous to that found in several apoptotic molecules. Bcl10 and E10 activated NF-kappaB but caused apoptosis of 293 cells. Bcl10 expressed i...
This study reveals the essence of ligand recognition mechanisms by which calmodulin (CaM) controls a variety of Ca(2+) signaling processes. We study eight forms of calcium-loaded CaM each with distinct conformational states. Reducing the structure to two degrees of freedom conveniently describes main features of the conformational changes of CaM via simultaneous twist-bend motions of the two lo...
ADAMTS1/METH1 belongs to the ADAMTS (a disintegrin and metalloprotease with thrombospondin repeats) family of proteins that currently comprises 18 members. Targeted inactivation of the ADAMTS1 gene results in morphological defects in the kidney, adrenal gland, and adipose tissue in addition to growth retardation and infertility in females. To gain further insight on the biology of ADAMTS1, we e...
Fibroblast growth factors (FGFs) are structurally related mitogens that can regulate the differentiation of a wide variety of cells. As a step towards elucidating the developmental roles played by one of these factors, we have used in situ hybridization methods to examine expression of the murine F gf-5 gene during embryogenesis. F gf-5 RNA was detected at seven distinct sites in the developing...
We study the problem of quadruple extensions of simple Lie algebras. We find that, adding a new simple root α+4, it is not possible to have an extended Kac-Moody algebra described by a Dynkin-Kac diagram with simple links and no loops between the dots, while it is possible if α+4 is a Borcherds imaginary simple root. We also comment on the root lattices of these new algebras. The folding proced...
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