The Hepatitis C virus E1 and E2 envelope proteins are the major players in all events required for virus entry into target cells. In addition, the recently developed HCV cell culture system has indicated that E1E2 heterodimer formation is a prerequisite for viral particle production. In this paper, we explored a new genetic approach to construct intergenotypic 2a/1b chimeras, maintaining the st...

Robin Harte Dedicated to Goldie Hawn, on her birthday Abstract We attempt to deconstruct the Arens-Royden Theorem. Suppose A is a Banach algebra (by default complex, with identity 1): we shall write 0.1 A−1 = {a ∈ A : 1 ∈ Aa∩aA} for the open subgroup of invertible elements, and A−1 0 for the connected component of the identity in A −1: it turns out ([8], [11] Theorem 7.11.4) that 0.2 A−1 0 = Ex...

We use a glass box approach based on decision trees to understand glycoprotein binding with biomedical polymers.

introduction: in order to determine the multidrug resistance (mdr) phenotype due to p-glycoprotein expression in haematological malignancies including acute myeloblastic leukemia (aml), a well-characterized p-gp expressing cell line was required to validate and standardize flow cytometric assays and to calibrate instruments. therefore, this resistant subline of k562 was established for the firs...

Vector algorithms allow the computation of an output vector r = r1r2 : : : rm given an input vector e = e1e2 : : : em in a bounded number of operations, independent of m the length of the vectors. The allowable operations are usually restricted to bit-wise operations available in processors, including shifts and binary addition with carry. These restrictions imply that the existence of a vector...

glanzmann’s thrombasthenia (gt) is an autosomal recessive inherited platelet function defect characterized by normal platelet count, prolonged bleeding time and abnormal clot retraction. this disease typically presents in infancy or early childhood and has proven to have very good prognosis. in this case study, a 22‑year‑old gt patient who also developed human immunodeficiency virus (hiv) infec...

Atomistic glycoprotein simulations reveal a site-specific availability of glycan substrates in time-resolved mass spectrometry maturating enzyme kinetics.

background and aims: herpes simplex virus type 1 (hsv1) remains a potentially serious health problem world wide. all infected people, including asymptomatic ones, are potential sources for virus transmission. virus envelope contains at least 13 glycoproteins, which glycoprotein d is the major target of immune responses. the aim of this study was development of a specific method that is a more r...