1Research Division, The Peter MacCallum Cancer Centre, East Melbourne, Australia; 2Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia; 3Department of Clinical Haematology, Monash Medical Centre, Clayton, Australia; 4Memorial Sloan-Kettering Cancer Center, New York, NY; 5The Hebrew University Hadassah Medical School, Jerusalem, Israel; 6Department of An...

The high-risk human papillomavirus E6 proteins have been shown to interact with and lead to degradation of PDZ-domain-containing proteins through its carboxy-terminal motif. This PDZ-binding motif plays important roles in transformation of cultured cells and carcinogenesis of E6-transgenic mice. However, its biological effects on the natural host cells have not been elucidated. We have examined...

The E6 oncoprotein from high-risk genus alpha human papillomaviruses (α-HPVs), such as HPV 16, has been well characterized with respect to the host-cell proteins it interacts with and corresponding signaling pathways that are disrupted due to these interactions. Less is known regarding the interacting partners of E6 from the genus beta papillomaviruses (β-HPVs); however, it is generally thought...

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