Atherosclerosis is the leading cause of death in the Western World and has been for decades a field of intense research. Yet, while there is a rich and diverse literature describing in detail the players and mechanisms involved in this complex disease in cell and animal models, we remain today with virtually no reliable markers for early diagnosis and targeted treatments options. This review is...

Introduction: Several studies have indicated that late treatment of aminoguanidine (AG) reduces cerebral ischemic injuries in animal models. However, the effects of early treatment of AG on cerebral ischemic damage are not well understood. This study was designed to evaluate effect of early treatment of AG on cortex and striatum injuries as well as neurological dysfunctions in transient mode...

In some cases, such as in the estimation of impulse responses, it has been found that for plausible sample sizes the coverage accuracy of single bootstrap confidence intervals can be poor. The error in the coverage probability of single bootstrap confidence intervals may be reduced by the use of double bootstrap confidence intervals. The computer resources required for double bootstrap confiden...

This paper develops a multiobjective programming model for the optimal allocation of passenger train services on an intercity high-speed rail line without branches. Minimizing the operator's total operating cost and minimizing the passenger's total travel time loss are the two planning objectives of the model. For a given many-to-many travel demand and a speci®ed operating capacity, the model i...

Buildings represent the largest potential for carbon reduction worldwide. This highlights need a simulation and optimization method energy management. The early design stage of buildings represents an important phase in which choices can be made to optimize parameters. These parameters focus on multiple areas, including thermal comfort. paper introduces early-stage sustainable building consider...

Abstract Simulation of the Hubbard model is a leading candidate for first useful applications fault-tolerant quantum computer. A recent study algorithms early simulations [Kivlichan et al 2019 Quantum 4 296] found that lowest resource costs were achieved by split-operator Trotterization combined with fast-fermionic Fourier transform (FFFT) on an L × lattice length = 2 k . On lattices ≠ , Givens...

background: breast cancer is the most common cancer among women worldwide. because of unknown etiology of cancer there is no specific existing method to prevent this diseases. annual mammography is considered the most valuable tool for detecting breast cancer in the earliest possible stages. this study was conducted to determine the effects of an education program on promoting mammography behav...