Since March 10, 2014, Guinea, Liberia, and Sierra Leone have experienced the largest known Ebola virus disease (Ebola) epidemic with approximately 13,000 persons infected as of October 28, 2014. Before September 25, 2014, only four patients with Ebola had been treated in the United States; all of these patients had been diagnosed in West Africa and medically evacuated to the United States for c...

1Department of Medicine, Royal Inland Hospital, Kamloops, British Columbia; 2Departments of Medicine, Critical Care Medicine, Pathology and Laboratory Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta; 3Department of Microbiology-Infectious Diseases, Université de Sherbrooke, Sherbrooke, Quebec Correspondence: Dr Kevin B Laupland, Royal Inland Hospital, 311 Columbi...

This clinical review has been developed for The BMJ in collaboration with BMJ Best Practice, based on a regularly updated web/mobile topic that supports evidence-based decision making at the point of care. To view the complete and current version, please refer to the Ebola virus infection topic on the BMJ Best Practice website. Ebola virus disease is a severe, often fatal, zoonotic filovirus in...

BACKGROUND In the current Ebola epidemic in Western Africa, many healthcare workers have become infected. Some of these have been medically evacuated to hospitals in Europe and the USA. These clinical experiences provide unique insights into the course of Ebola virus disease under optimized condition within high level isolation units. CASE PRESENTATION A 50-year-old Caucasian male physician c...

The Ebola Hemorrhagic Fever, caused by the virus, is a rare but severe disease and claims fatality rate of 50%. Although its origins date back to 1970s, epidemic in 2014-2016 marked most prominent appearance.

Ebola virus is named after the river in the former Zaire where a haemorrhagic fever initially identified in 1976 involved human to human transmission, as well as spread by contaminated injection equipments [1]. Ebola virus causes an acute febrile illness associated with a high mortality rate. The illness is characterized by multi-system involvement that begins with abrupt onset of headache, mya...

Ebola virus disease afflicts both human and animal populations and is caused by four ebolaviruses. These different ebolaviruses may have distinct reservoir hosts and ecological contexts that determine how, where, and when different ebolavirus spillover events occur. Understanding these virus-specific relationships is important for preventing transmission of ebolaviruses from wildlife to humans....

We previously developed optimized DNA vaccines against both Lassa fever and Ebola hemorrhagic fever viruses and demonstrated that they were protective individually in guinea pig and nonhuman primate models. In this study, we vaccinated groups of strain 13 guinea pigs two times, four weeks apart with 50 µg of each DNA vaccine or a mock vaccine at discrete sites by intradermal electroporation. Fi...

The current Ebola virus disease (EVD) outbreak in West Africa—the worst since Ebola virus was identified in 1976—provides a stark reminder of the human consequences of EVD. There are great challenges, ethical dilemmas and uncertainty in providing safe obstetric interventions to Ebola virus-infected women in a humanitarian emergency setting. Although applying the precautionary principle is emine...