Objective(s): Filamentous bacteriophage M13 was genetically engineered to specifically target mammalian cells for gene delivery purpose. Materials and Methods: A vascular endothelial growth factor receptor 2 (VEGFR2)-specific nanobody was genetically fused to the capsid gene III of M13 bacteriophage (pHEN4/3VGR19). A mammalian expression construct containing Cop-green fluorescent protein (Cop-G...

vascular endothelial growth factor receptor-2 (vegfr-2); a cell surface receptor for vascular endothelial growth factors, is a key pharmacological target involved in the cell proliferation/angiogenesis. it has been revealed that vegfr-2 induces proliferation through activation of the extracellular signal-regulated kinases pathway. in this regard, targeting the vegfr-2 has been considered as an ...

Objective(s): To investigate the role of autophagy in advanced glycation end products (AGEs)-induced proliferation and migration in rat vascular smooth muscle cells (VSMCs).Materials and Methods: After culture, VSMCs were treated with 0, 1, 10, and 100 μg/ml concentrations of AGEs. Autophagy specific protein light chain 3 (LC3)-I/II was determined by western blotting, autophagosomes were observ...

BACKGROUND The A10 and A7r5 cell lines derived from the thoracic aorta of embryonic rat are widely used as models of non-differentiated, neonatal and neointimal vascular smooth muscle cells in culture. The recent discovery of resident multipotent vascular stem cells within the vessel wall has necessitated the identity and origin of these vascular cells be revisited. In this context, we examined...

vascular lesions rise from abnormalities in blood vessels or endothelial proliferation . capillary hemangiomas are formed by small capillaries surrounded by a layer of endothelial cells in a connective tissue stroma . various treatments are used for these conditions like excisional surgery , sclerotherapy, and recently laser irradiation. in this case study, we report successful treatment of int...

purpose : to report clinical and pathologic result of a young patient with isolated cavernous hemangioma of conjunctiva case report : a 26-year-old man who presented with smooth, red, lobular surface mass was seen in the bulbar conjunctiva in temporal side with engorged episcleral and conjunctival vessels around the lesion. excisional biopsy was performed. pathologist confirmed the diagnosis of...

hemangioma of the ovary is reported in a 66 years old woman. vascular tumors of the female genital tract are rare, especially those of the ovaiy. most cases are discovered incidentally. the case presented here was missed clinically.