This study investigated the effects of acoustic noise on the auditory nerve compound action potentials in response to electric pulse trains. Subjects were adult guinea pigs, implanted with a minimally invasive electrode to preserve acoustic sensitivity. Electrically evoked compound action potentials (ECAP) were recorded from the auditory nerve trunk in response to electric pulse trains both dur...

Networks of electrically coupled neurons play an important role in coordinating activity among widely distributed neurons in the CNS. Such networks are sensitive to neuromodulation; but how modulation of individual cells affects activity of the entire network is not well understood. In the CNS of the medicinal leech, the S interneuron (S-cell) forms a network of electrically coupled neurons whe...

We studied the effects of supplementing nitrous oxide-oxygen anaesthesia with halothane (1 MAC end-tidal concentration) on the motor evoked potential recorded in the extradural space of eight patients before corrective surgery for idiopathic adolescent scoliosis. The motor cortex was stimulated electrically through the scalp. An additional eight patients in whom anaesthesia was supplemented wit...

Experimental electrophysiological assessment of evoked responses from regenerating nerves is challenging due to the typical complex response of events dispersed over various latencies and poor signal-to-noise ratio. Our objective was to automate the detection of compound action potential events and derive their latencies and magnitudes using a simple cross-correlation template comparison approa...

Parkinson’s disease (PD) is a common neurodegenerative disease, pathologically characterized by the progressive degeneration of dopaminergic neurons in substantia nigra. Although various biomarkers and imaging criteria for PD have been established, objective reliable evaluation methods are still lacking. Electroneurography, as an measurement evoked compound muscle action potentials, used to ass...