The aim of the present study was to develop and investigate the feasibility of delivering Nebivolol as a transdermal patch by iontophoresis. The passive and electrically assisted transdermal delivery of Nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. Because of its extensive hepatic metabolism and low dos...

Osmosis is the movement of solvent across a membrane induced by a solute-concentration gradient. It is very important for cell biology. Recently, it has started finding technological applications in the emerging processes of Forward Osmosis and Pressure-Retarded Osmosis. They use ultrathin and dense membranes supported mechanically by much thicker porous layers. Until now, these processes have ...

The technique to fabricate nanofibrous mat by electro-spinning has been known for a long time. But the attempts to use the electospun nanofiber mats, also known as electro-spun nanofiber membranes (ENMs), for filtration purposes began only recently. Among many membrane filtration processes, air cleaning by the removal of dust particles has already been commercialized and the product has been in...

In-depth quantitative visualization studies are required to understand the flow induced by swimming micro-organisms and find potential applications. The present study visualized the flow induced by Tetrahymena pyriformis of size 45–50 lm, which swam freely and via stimulation by galvanotaxis in a PDMS micro-chamber using a micro-particle image velocimetry system. The results showed that the max...

The area of 'laboratory-on-a-chip', miniaturised or microfluidic analysis systems, is a rapidly developing field. At the microscale, electrokinetic processes become enhanced, and the advent of AC electrokinetics (EK) in recent years further promotes the development of electrokinetic devices for microfluidics. ACEK has demonstrated to manipulate fluids and polarisable particles at low voltages w...

The nonlinear phenomena that occur in the electric double layer (EDL) that forms at charged surfaces strongly influence electrokinetic effects, including electro-osmosis and electrophoresis. In particular, saturation effects due to either dielectric decrement or ion crowding effects are of paramount importance. Dielectric decrement significantly influences the ionic concentration in the EDL at ...

Single-step fusion-based affinity purification of proteins with pH-controllable linkers was carried out in a fluidic device. The linkers were previously derived from self-splicing protein elements called inteins. Two different linkers were generated to solve two distinct separation problems: one for rapid single-step affinity purification of a wide range of proteins, and the other specifically ...

-------------------------------------------------------Abstract--------------------------------------------------------Fluoride is often described as a ‘double-edged sword’ as inadequate ingestion is associated with dental caries, where as excessive intake leads to dental, skeletal and soft tissue fluorosiswhich has no cure. Considering the fact that fluorosis is an irreversible condition and h...