Head direction (HD) cells in the rodent limbic system are believed to correspond to a cognitive representation of directional heading in the environment. Lesions of vestibular hair cells disrupt the characteristic firing patterns of HD cells, and thus vestibular afference is a critical contributor to the HD signal. A subcortical pathway that may convey this information includes the dorsal tegme...

SLUMMARY Both hemodynamic and electrocardiographic effects of Renografin-76 (diatrizoate meglumine) were studied in intact, anesthetized dogs. The left coronary artery in nine dogs was injected with equal amounts of Renografin-76, an equiosmolar dextrose solution (1690 mOsm/1) and a solution of the same electrolytic content (190 mEq/l sodium). Renografin and the dextrose solution produced signi...

Acute electrolytic lesions of the commissural nucleus of the solitary tract (commNTS) reduce blood pressure (BP) in SHR but not in normotensive Wistar-Kyoto and Wistar rats and abolish the pressor response to intravenous injection of potassium cyanide. We investigated the chronic effect of commNTS lesions on mean arterial pressure (MAP), and on baroreceptor and chemoreceptor reflex responses in...

Lesions of the dorsal premammillary nucleus (PMd) have been reported to produce dramatic reductions in responsivity of rats to a live cat. Such lesions provide a means of analyzing the potentially differential neural systems involved in different defensive behaviors, and the relationship between these systems and concepts such as anxiety. Rats with bilateral electrolytic lesions of the PMd were...

LEUNG, PHILIP M.-B., AND QUINTON R. ROGERS. Importance of prepyriform cortex in food-intake response of rats to amino acids. Am. J. Physiol. 221(3): 929-935. 197 1 .-Bilateral electrolytic lesions were placed in the prepyriform cortex of male 230to 250-g rats and their food intake as affected by amino acid imbalance, deficiency, and excessive protein was examined. All rats with such lesions and...

The development of methods and apparatus for magnetic measurements capable of an accuracy of i per cent makes it necessary to consider factors which have heretofore been considered negligible. One of these factors, the temperature coefficient of magnetic permeability, is the subject of the present paper. Many workers have studied the effects of temperature on the magnetic permeability of iron a...

Introduction: The antinociceptive effect of morphine is, in part, mediated through the activation of a descending pathway. One of the major components of this pathway is the nucleus raphe magnus (NRM). Our previous study demonstrated the involvement of NRM in the analgesic effect of morphine microinjected into the nucleus cuneiformis (NCF) in a descending manner. The aim of the current study...

vious experiment (Table 1). It could be argued that after a nearly complete depletion of norepinephrine an additional small and undetectable decrease in norepinephrine might surpass some critical threshold and lead to the release of eating. However, if this were true we would also expect this threshold would have been surpassed in at least some of the more than 150 rats in our laboratory which ...

Limbic forebrain inhibits growth and growth hormone (GH) secretion in mature golden hamsters as shown by acceleration of growth and increases in serum GH concentrations following the electrolytic lesions of septum, transection of the hippocampus and surgical separation of these two regions. The growth-inhibitory function of this circuit is most probably mediated by somatostatinergic (SRIF) neur...