In this paper, the anticonvulsant characteristics of doxepin were evaluated in numerous experimental seizure models, including maximal electroshock (MES)-, pentylenetetrazole (PTZ)-, isoniazid (ISO)-, 3-mercaptopropionic acid (3-MP)-, bicuculline (BIC)-, thiosemicarbazide (THIO)-, and strychnine (STR)-induced seizures. In addition, the acute adverse-effect profile of doxepin with respect to imp...

This article reframes electroconvulsive therapy as a form of violence against women. Drawing on women's testimony and on scientific research, it establishes that this "treatment," which is overwhelmingly given to women, results in extensive cognitive and physical impairment. Correspondingly, it functions and is experienced as a form of assault and social control, not unlike wife battery. Emerge...

BACKGROUND Cardiac dysfunction is one of the possible causes of sudden unexpected death in epilepsy (SUDEP). Therefore, it was the objective of this study to evaluate the cardiac and electrocardiographic parameters after seizures induced by maximal electroshock (MES) in Wistar rats. METHODS Electroshock seizures were induced in Wistar rats through a pair of ear-clip electrodes (10 mA at a fre...

LTHOUGH clinical studies on the efficacy of desoxycorticosterone therapy A in epilepsy have yielded contradictory results (I, 2), in a few cases a significant decrease in the incidence of grand ma1 seizures has been noted (2). This improvement in the clinical status of the patients was apparently due to a retention of Na in the body, and a loss of K (3). Spiegel (4) administered desoxycorticost...

Creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. Creatine supplements have shown beneficial effects on neurological disorders including Parkinson׳s disease, Huntington›s disease, amyotrophic lateral sclerosis, as well as Alzheimer›s disease and stroke. However, the potential benefits of creatine for patients...

The effect of a selective adenosine antagonist, 8-cyclopentyl 1,3-dimethylxanthine (8-CPT) was used to examine involvement of adenosine in ictal and postictal events in rats subjected to maximal electroshock (MES). MES induces the ictal event of hindlimb tonic extension (HLTE) followed by postictal depression (PID). 8-CPT 10 mg/kg, ip produced maximal significant reduction of PID without affect...

Purpose: The objective of the present manuscript is to propose a step-by-step algorithm for management calcifying tendonitis (CT) shoulder based on treatment goals, from conservative surgical approaches. Method: A clinical note main treatments pain, rigidity and size calcification experience previous publications authors has been performed. Arguments: Treatment although there controversy most a...

Paeonia Radix is one of the most commonly used herbal drug in traditional Chinese medicine1 and folkloric medicine of different countries since ancient times2. A number of chemical and pharmacological studies have been conducted on the roots of Paeonia species. Monoterpen glycosides are the active constituents, among them; paeoniflorin is the main compound in genus Paeonia3. In traditional medi...

The microscopic nematode Caenorhabditis elegans has emerged as a valuable model for understanding the molecular and cellular basis of neurological disorders. The worm offers important physiological similarities to mammalian models such as conserved neuron morphology, ion channels, and neurotransmitters. While a wide-array of behavioral assays are available in C. elegans, an assay for electrosho...

A series of p-nitrophenyl substituted semicarbazones (4a-c) and phenoxy/p-bromophenoxy acetyl hydrazones (8a-q) were synthesized and their anticonvulsant activity was screened against maximal electroshock seizure (MES), subcutaneous metrazole (ScMet) and subcutaneous strychnine (ScSty) tests. Compounds 4a-c with -NHCO- were found to be the most active in all these tests. These compounds were al...