ELF/VLF waves can be generated via amplitude modulated HF heating of the auroral electrojet, which turns a patch of ionospheric currents into a radiating antenna. A new, more powerful technique, termed `geometric modulation', involves scanning the HF beam in geometric patterns with no power modulation. Utilizing results obtained from the HAARP facility, we show that geometric modulation enhance...

Previous studies have shown that the male reproductive system is one of the most sensitive organs to electromagnetic radiation. However, the biological effects and molecular mechanism are largely unclear. Our study was designed to elucidate the epigenetic effects of 50 Hz ELF-EMF in vitro. Mouse spermatocyte-derived GC-2 cell line was exposed to 50 Hz ELF-EMF (5 min on and 10 min off) at magnet...

Background/Aims Liver stiffness (LS) was assessed using transient elastography, and the enhanced liver fibrosis (ELF) test was performed to accurately assess fibrotic burden. We validated the LS-ELF algorithm and investigated whether the sequential LS-ELF algorithm performs better than concurrent combination of these analyses in chronic hepatitis B (CHB) patients. Methods Between 2009 and 201...

Increasing knowledge has accumulated relating to the effect of cigarette smoking on cells and other constituents in bronchoalveolar lavage (BAL) fluid. Such knowledge is important for the correct evaluation of BAL results. When BAL records are interpreted, smoking has to be considered as a major confounding factor. In this issue of the Journal, BuRKE et al. [1] add a new aspect to the adverse e...

OBJECTIVE To examine the association between occupational exposure to extremely-low-frequency magnetic fields (ELF-MF) and Parkinson's disease. METHODS We systematically searched publications reporting risk estimates of Parkinson's disease in workers exposed to ELF-MF. Summary relative risks were obtained with random effects meta-analysis. RESULTS We included 11 studies. To assign exposure,...

This study was aimed to observe that extremely low frequency magnetic field (ELF-MF) may be relevant to changes of major neurotransmitters in rat brain. After the exposure to ELF-MF (60 Hz, 2.0 mT) for 2 or 5 days, we measured the levels of biogenic amines and their metabolites, amino acid neurotransmitters and nitric oxide (NO) in the cortex, striatum, thalamus, cerebellum and hippocampus. The...

A single inhaled dose of laninamivir octanoate (LO), a long-acting neuraminidase inhibitor, exhibits efficacy in treating both adult and pediatric patients with influenza virus infection. The intrapulmonary pharmacokinetics (PK) of LO and laninamivir, a pharmacologically active metabolite, were investigated by a single-center, open-label study of healthy adult volunteers. Subgroups of five subj...

Vancomycin penetration into the fluid lining the epithelial surface of the lower respiratory tract was studied by performing fiberoptic bronchoscopy with bronchoalveolar lavage on 14 critically ill, ventilated patients who had received the drug for at least 5 days. The apparent volume of epithelial lining fluid (ELF) recovered by bronchoalveolar lavage was determined by using urea as an endogen...

Extremely low frequency magnetic fields (ELF-MF) have the ability to produce a variety of behavioral and physiological changes in animals. The stomach, as the most sensitive part of the neuroendocrine organ of the gastrointestinal tract, is crucial for the initiation of a full stress response against all harmful stress. Thus, the purpose of this study was to examine whether ELF-MF stimuli induc...