gastric emptying is a complex and extremely variable process. this causes the unpredictability of the bioavailability of drug delivery systems. gastro retentive drug delivery systems (grdds)s have received significant interest in the past decades as they can overcome the limitation of conventional oral controlled release drug delivery systems related to fast gastric emptying time. an optimum gr...

The current work involves preparation and evaluation of self-micro emulsifying drug delivery system carvedilol, an nonselective betablocker alpha-1 blocker. Oral self micro-emulsifying Carvedilol were prepared by studying the solubility in different oils, surfactants co-surfactants formulations using mixtures surfactants, cosurfactants various proportions. Based on study, optimised carvedilol w...

The improvement of bio-availability of drugs presents one of the greatest challenges in drug formulations. One of the most popular and commercially viable formulation approaches for this challenge is self-micro emulsifying drug delivery systems (SMEDDS). 1 SMEDDS are defined as isotropic mixtures of natural or synthetic oils, solid or liquid surfactants, or alternatively, one or more hydrophili...

nowadays, environment-sensitive smart drug delivery systems have found diverse applications in pharmaceutical science and technology. these systems can respond to the environment stimuli such as temperature, pressure, ph, light, electrical and magnetical fields and etc. they can release the proper amount of drug in human body. among these systems, special attention and much research works have ...