Prokineticins and their receptors are expressed in various cellular compartments in human endometrium, with prokineticin 1 (PROK1) showing a dynamic pattern of expression across the menstrual cycle and during pregnancy. Previous studies suggest that PROK1 can play an important role in implantation and early pregnancy by inducing vascular remodeling and increasing vascular permeability. Here we ...

The matrix metalloproteinase (MMP) system is composed of the enzymatic component, the MMPs, and the enzyme inhibitory component, the tissue inhibitors of metalloproteinases or TIMPs. It is well established that the MMP system plays a critical role during the normal development and growth of the endometrium as well as many other physiological processes. Because of the necessity for the balance b...

Background: Endometrial hyperplasia is important clinically, because it can lead to abnormal uterine bleeding (AUB) which itself can precede to endometrial cancer. Endometrial carcinoma is the most common malignancy of the female genital tract, occurring about 75-85% in younger, perimenopousal women as hyperplasic endometrial. The treatment is hysterectomy or hormone therapy with progesterone. ...

OBJECTIVE Mouse bone marrow mesenchymal stem cells (BMSCs) have been demonstrated to differentiate into female endometrial epithelial cells (EECs) in vivo. Our previous studies demonstrated that BMSCs can differentiate in the direction of EECs when co-cultured with endometrial stromal cells in vitro. Here, we obtain and analyse differential proteins and their relevant pathways in the process of...

Chlamydia trachomatis infections represent the predominant cause of bacterial sexually transmitted infections. As an obligate intracellular bacterium, C. trachomatis is dependent on the host cell for survival, propagation, and transmission. Thus, factors that affect the host cell, including nutrition, cell cycle, and environmental signals, have the potential to impact chlamydial development. Pr...

Background Ovarian angiogenesis (OA) remains in lifetime and normal ovarian function depends to this continual remodeling of a complex vascular system. Endometrial thickness (ET) is one of the strongest predictors of successful implantation and pregnancy. Appropriate OA effects on ET by facilitating of ovarian hormone delivery. Materials and Methods Thirty adult female mice and twenty adult m...

objectives : bone remodeling occurs during orthodontic treatment; this process enables tooth movement. many factors can affect bone remodeling at the cellular level, such as nutritional supplements that can affect tooth movement. the present study was designed to evaluate the effect of dietary vitamin c on orthodontic tooth movement in rats.  materials and methods: this study was carried out on...

hedera helix  is widely used to treat bronchial asthma for many years. however, effects of this herb on lung histopathology is still far from clear. we aimed to determine the effect of oral administration of hedera helix on lung histopathology in a murine model of chronic asthma. balb/c  mice  were  divided  into  four  groups;   i  (placebo),  ii  (hedera  helix), iii (dexamethasone) and iv (c...

Endometriosis is a common reproductive disorder believed to be associated with matrix metalloproteinases (MMPs) activities for invasion and remodeling of endometrial tissues. Ectopic endometrium has higher capacity to produce proMMP-2 than eutopic tissues; however, the role of MMP-2 during early phase of endometriosis development is still unclear. In the present study, we investigated the role ...

No other tissue in the body undergoes such a vast and extensive growth and remodeling in a relatively short period of time as the primate endometrium. Endometrial integrity is coordinated by ovarian hormones, namely, estrogens, progesterone, and the embryonic hormone chorionic gonadotropin (CG). These regulated events modulate the menstrual cycle and decidualization. The Notch family of transme...