Endomyocardial fibrosis (EMF) is a restrictive cardiomyopathy of unknown etiology. It is mainly prevalent in the tropical and subtropical countries. The aim of this study was to evaluate the diagnostic value of endomyocardial biopsy (EMB) for EMF, and detect the relationship between Coxsackie virus B3 (CVB3) and EMF in the Chinese patients. The right ventricular EMB was performed in 18 patients...

Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and death. Myocardial fibrosis results from increased myofibroblast activity and excessive extracellular matrix deposition. Various cells and molecules are involved in this process, providing targets for potential drug therapies. Currently, the main detection methods of myocardial fibrosis rely on serum m...

Endomyocardial fibrosis is a very rare form of heart disease in temperate climates but is fairly common in tropical and sub-tropical parts of Africa. Since Bedford and Konstam (1946) first described the disease in West African soldiers, many reports have appeared from various parts of Africa: from Uganda (Davies, 1948), the Sudan (O'Brien, 1954), Nigeria (Nwokolo, 1955; Abrahams, 1959, 1962), a...

Endomyocardial fibrosis is a common cause of heart failure in Uganda. A clinico-pathological study of this cardiopathy reported by Ball et al. (1954) established that the fibrotic process, while involving the endocardium of the apices of the ventricles, not infrequently extends to the chorda, tendinee and the cusps of the atrioventricular valves, tethering them down and producing atrioventricul...

Introduction Endomyocardial fibrosis (EMF) is a restrictive cardiomyopathy presenting with ventricular apical filling, possibly containing fibrotic tissue with thrombus and/or calcification. Late gadolinium enhancement (LGE) can detect apical fibrosis in EMF patients, as a hyper intense linear image usually in a letter “V” like shape pointing to the ventricular apex. Recently, we have observed ...

We report on a case of adriamycin cardiotoxicity occurring in a five-year-old boy treated for rhabdomyosarcoma. In addition to the usual features of myofibrillary degeneration associated with adriamycin, extreme endocardial fibrosis and mural thrombosis affecting the apical segments of both ventricles but particularly the left ventricle was seen at necropsy. The changes resembled classical endo...

Endomyocardial fibrosis is a form of endemic restrictive cardiomyopathy that affects mainly children and adolescents, and is geographically restricted to some poor areas of Africa, Latin America and Asia. It is a condition with high morbidity and mortality, for which no effective therapy is available. Although several hypotheses have been proposed as triggers or causal factors for the disease, ...