نتایج جستجو برای: endothelial nitric oxide synthase

تعداد نتایج: 351879  

2014
KAP Wijnands DM Meesters B Vandendriessche JJ Briedé BAP Bessems HMH van Eijk P Brouckaert WAP Buurman A Cauwels M Poeze

Introduction Sepsis is associated with high mortality rates as a result of the development of multiple organ failure (MOF). In MOF the competition for the amino acid arginine between the microcirculation and the inflammatory response is important. The endothelial nitric-oxide synthase (eNOS) uses arginine to produce nitric oxide (NO), which results in microcirculatory vasodilatation, whereas ar...

Journal: :مجله دانشگاه علوم پزشکی مازندران 0
عبدالکریم مهروز a.k mahrooz phd. student. dept. of biochemistry, tabriz university of medical sciences محمد انصاری m ansari احمد شریف تبریزی a sharif tabrizi

background and purpose: during recent years, nitric oxide (no) has been considered as a molecule involved in migraine headaches. this free radical involves in initiation of migraine headaches via no/cgmp signaling pathway and vascular relaxation specially big intracranial arteries. therefore, we studied the effects of aqueous extract of origanum vulgare and melilotus officinalis prescribed in m...

Journal: :Biochemical Society transactions 1993
J S Beckman J P Crow

Introduction Approximately 6 years ago, nitric oxide was identified as the endothelium-derived relaxing factor (EDRF), the endogenous vasodilator mimicked by nitroglycerin and nitroprusside [ 1-41. An astonishing variety of tissues synthesize nitric oxide, which has important roles in the control of systemic blood pressure, respiration, digestion, penile erection, platelet aggregation, cerebral...

2007
Bonnie L. Goodwin Laura C. Pendleton Monique M. Levy Larry P. Solomonson Duane C. Eichler

Goodwin BL, Pendleton LC, Levy MM, Solomonson LP, Eichler DC. Tumor necrosis factorreduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells. Am J Physiol Heart Circ Physiol 293: H1115–H1121, 2007. First published May 11, 2007; doi:10.1152/ajpheart.01100.2006.—Endothelial dysfunction associated with elevated serum levels of TNFobserved in diabetes, ob...

2016
Junqiang Yan Jiachun Sun Xiangming Li Mingming Zhai Xiaofei Jia

Statins can induce neuroprotective effects by various mechanisms, such as by lowering cholesterol levels; decreasing β-amyloid production, serum apolipoprotein E (APOE) levels, and anti-inflammatory responses; modifying cognition-related receptors, and augmenting endothelial nitric oxide synthase. The use of statins has been related to many neurodegenerative conditions, such as Alzheimer’s dise...

Journal: :Planta medica 2018
Bruno Rodrigo Minozzo Daniel Fernandes Flávio Luís Beltrame

Endothelial dysfunction is characterised by the low bioavailability of nitric oxide with a relevant negative impact on the nitric oxide/cGMP pathway. The loss of nitric oxide/cGMP signaling may be caused by an increased arginase activity. Plant-derived substances, especially polyphenols, are compounds that have the potential to inhibit arginase activity and they may represent an attractive ther...

Journal: :Planta medica 2016
Alexandra Gerstgrasser Sigrid Röchter Dirk Dressler Christiane Schön Claudia Reule Sybille Buchwald-Werner

Mangifera indica fruit preparation (Careless™) activates the evolutionary conserved metabolic sensors sirtuin 1 and adenosine monophosphate-activated protein kinase, which have been identified as playing a key role in microcirculation and endothelial function. Here, an acute effect of a single dose of 100 mg or 300 mg Careless™ on microcirculation was investigated in a randomized, double-blind,...

Journal: :iranian journal of pharmaceutical research 0
mk gharib naseri m navid hamidi a heidari

reports have shown the antioxidant, hypotensive, hypolipidemic and vasodilatory effects of grape (vitis vinifera l.) seed extract. we have recently shown the relaxatory effect of grape leaf extract on rat uterus and reduction of frog heart rate and contractility. the aim of the present study was to investigate the relaxant effect of vitis vinifera leaf hydroalcoholic extract (vlhe) on rat thora...

Journal: :Revista espanola de cardiologia 2015
Gemma Vilahur Teresa Padró Laura Casaní Guiomar Mendieta José A López Sergio Streitenberger Lina Badimon

INTRODUCTION AND OBJECTIVES The Mediterranean diet, rich in polyphenols, has shown to be cardioprotective. However the mechanisms involved remain unknown. We investigated whether supplementation with a pomegranate extract rich in polyphenols renders beneficial effects on coronary function in a clinically relevant experimental model and characterized the underlying mechanisms. METHODS Pigs wer...

2012
Ying-Ling Lai Susumu Tomono Noriyuki Miyoshi Hiroshi Ohshima

The cholesterol ozonolysis products secosterol-A and its aldolization product secosterol-B were recently detected in human atherosclerotic tissues and brain specimens, and have been postulated to play pivotal roles in the pathogenesis of atherosclerosis and neurodegenerative diseases. We examined several oxidized cholesterol metabolites including secosterol-A, secosterol-B, 25-hydroxycholestero...

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