This study demonstrates endothelium-dependent relaxation in the surface arterioles of the brain. A helium-neon laser was used to injure endothelium in situ following i.v. injection of Evans blue dye, which sensitizes the bed to the laser. Areas 18 or 36 micron in diameter were injured and no longer relaxed to either 1 ml of acetylcholine chloride or bradykinin triacetate, 80 micrograms/ml deliv...

Aim: This study aimed to investigate whether endothelium-dependent and -independent relaxation responses can be preserved intact in the rat thoracic aorta after storage for 3, 6, 18 hours Krebs-Henseleit solution at +4 °C.
 Methods: Isolated organ bath model 10-12 weeks old male Wistar rats were used perform experiments. To effect of factors, cyclooxygenase inhibitor INDO was added inhibit...