Human endothelial cells respond to bacterial endotoxin (lipopolysaccharide [LPS]) with changes that transform the endothelium into a surface with prominent procoagulant properties. Production of tissue factor (TF) in response to LPS is a major alteration that favors coagulation. Biologic activities of LPS have previously been shown to be enhanced by the presence of hemoglobin. Therefore, the ab...

Tissue factor pathway inhibitor (TFPI), the main inhibitor of initiation of coagulation, exerts an important anticoagulant role through the factor Xa (FXa)-dependent inhibition of tissue factor/factor VIIa. Protein S is a TFPI cofactor, enhancing the efficiency of FXa inhibition. TFPI can also inhibit prothrombinase assembly by directly interacting with coagulation factor V (FV), which has been...

Tissue factor (TF), an initiator of the extrinsic blood coagulation cascade, is overexpressed in different types of cancer. Tissue factor overexpression is also known as a poor prognostic factor in pancreatic cancer. We recently developed anti-TF antibody (clone1849)-conjugated epirubicin-incorporating micelles (NC-6300), and reported that this anti-TF1849-NC-6300 showed enhanced antitumor acti...

 It has been recognized that patients with Cyanotic Congenital Heart Disease (CCHD) show significant bleeding tendency which can be secondary to coagulopathies in these patients. Some coagulation abnormalities are thrombocytopenia, factor deficiencies, fibrinolysis and Disseminated Intravascular Coagulation  (DIC). According to high prevalence of CCHD and major operations in theses patients, th...

it has been recognized that patients with cyanotic congenital heart disease (cchd) show significant bleeding tendency which can be secondary to coagulopathies in these patients. some coagulation abnormalities are thrombocytopenia, factor deficiencies, fibrinolysis and disseminated intravascular coagulation  (dic). according to high prevalence of cchd and major operations in theses patients, the...

In the course of studies of the effect of heat on the proteins of human serum it was observed that, at pH 7.4, minute amounts of sodium iodoacetate completely prevented thermal coagulation, while traces of mercaptans markedly enhanced the coagulation. The present paper is an analysis of these observations. The thermal coagulation of a protein, such as egg albumin, has been postulated (1) to con...

Arsenic is a naturally occurring contaminant in waters, which toxic and adversely affects human health. Therefore, treatment of water for arsenic removal very important production safe drinking water. Coagulation using Fe(III) salts the most frequently applied technology removal, but efficient mostly As(V) removal. As(III) usually requires application pre-oxidation step, mainly conducted by che...

In the course of studies of the effect of heat on the proteins of human serum it was observed that, at pH 7.4, minute amounts of sodium iodoacetate completely prevented thermal coagulation, while traces of mercaptans markedly enhanced the coagulation. The present paper is an analysis of these observations. The thermal coagulation of a protein, such as egg albumin, has been postulated (1) to con...

background: although stabilization ponds and lagoons are suitable treatment processes due to simplicity of operation and low per capital costs, the effluents of these systems have too high of a total suspended solids concentration to be discharged into receiving waters. this problem is mainly caused by algae. in this study, an electro-coagulation reactor was examined to re­move algae from the f...